9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

Base Information

Chemical Name:9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane
CAS No.:1228217-13-7
Molecular Formula:C₂₈H₂₈FN₇
Molecular Weight:481.576
Hs Code.:

Synonyms:9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

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Chemical Property of 9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

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Technology Process of 9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

There total 5 articles about 9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228217-26-2
tert-butyl 9-[2-(4-fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane-2-carboxylate

: 1228217-13-7
9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

Guidance literature:: tert-butyl 9-[2-(4-fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane-2-carboxylate; With hydrogenchloride; water; at 20 ℃; for 18h;

With sodium hydroxide; In water;

Reference yield:

: 1095708-39-6
6-chloro-2-(4-fluorophenyl)-3-iodoimidazo[1,2-b]pyridazine

: 1228217-13-7
9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 18 h / Inert atmosphere; Reflux

2: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 40 h / 140 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 60 °C

4: hydrogenchloride; water / 18 h / 20 °C

With hydrogenchloride; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; pentan-1-ol; water;

Reference yield:

: 244081-70-7
6-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine

: 1228217-13-7
9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 5 steps

1: Iodine monochloride / chloroform / 4 h / 0 - 20 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 18 h / Inert atmosphere; Reflux

3: N-ethyl-N,N-diisopropylamine / pentan-1-ol / 40 h / 140 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 60 °C

5: hydrogenchloride; water / 18 h / 20 °C

With hydrogenchloride; water; Iodine monochloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; pentan-1-ol; chloroform; water;