244081-70-7

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 

Downstream Products

• 1220351-62-1 6-chloro-2-(4-fluorophenyl)-3-(4-nitrophenyl)imidazo[1,2-b]pyridazine 
• 1105714-45-1 Ethyl 4-[6-chloro-2-(4-fluorophenyl)-imidazo[1,2-b]pyridazin-3-yl]-4H-pyridazine-1-carboxylate 
• 1095708-17-0 2-(4-fluorophenyl)-6-(N-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine 
• 1228216-91-8 2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine 
• 1228217-13-7 9-[2-(4-Fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane 
• 1228217-14-8 2-(4-fluorophenyl)-6-(4-pyrrolidin-1-ylpiperidin-1-yl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine 
• 1228217-22-8 6-chloro-2-(4-fluorophenyl)-3-{1-[(4-methylphenyl)sulphonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}imidazo[1,2-b]pyridazine 
• 1228217-23-9 2-(4-fluorophenyl)-6-[(3R)-3-methylpiperazin-1-yl]-3-{1-[(4-methylphenyl)sulphonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}imidazo[1,2-b]pyridazine 
• 1228217-25-1 tert-butyl 9-{2-(4-fluorophenyl)-3-[1-(4-methylphenylsulphonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]imidazo[1,2-b]pyridazin-6-yl}-2,9-diazaspiro[5.5]undecane-2-carboxylate 
• 1228217-26-2 tert-butyl 9-[2-(4-fluorophenyl)-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl]-2,9-diazaspiro[5.5]undecane-2-carboxylate 
• 1228217-27-3 2-(4-fluorophenyl)-6-(4-pyrrolidin-1-ylpiperidin-1-yl)-3-[1-(4-methylphenylsulphonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]imidazo[1,2-b]pyridazine 
• 1443986-22-8 2-(4-fluorophenyl)-6-(morpholin-1-yl)imidazo[1,2-b]pyridazine 
• 1443986-23-9 2-(4-fluorophenyl)-3-iodo-6-phenylimidazo[1,2-b]pyridazine 
• 1443986-24-0 2-(4-fluorophenyl)-3-iodo-6-(morpholin-1-yl)imidazo[1,2-b]pyridazine 

Relevant academic research and scientific papers

Reactivity of a 6-chloroimidazo[1,2-b]pyridazine derivative towards Suzuki cross-coupling reaction

The influence of base, reaction time and boronic acid in the Suzuki cross-coupling reaction on 6-chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine is reported. The crystal data for the thien-2-yl compound 7 is also described.

SUBSTITUTED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Imidazo[1,2-a]azine and their use as pharmaceuticals

Imidazo[1,2-a]azines and their use as pharmaceuticals The present invention relates to derivatives of imidazo[1,2-a]azines of the formula (I), in which X, R, R1 to R3 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of the formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of the formula I, to pharmaceutical compositions comprising them, and to the use of compounds of the formula I for the manufacture of a medicament for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.

Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands

The invention provides novel imidazo[1,2-b]pyridazines of formula (I) and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing diseases assoc