1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

Base Information

Chemical Name:1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester
CAS No.:1055320-90-5
Molecular Formula:C₂₆H₂₇NO₄
Molecular Weight:417.505
Hs Code.:

Synonyms:1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

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Chemical Property of 1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

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Technology Process of 1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

There total 10 articles about 1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1055320-89-2
1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, dimethyl ester

: 1055320-90-5
1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

Guidance literature:: 1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, dimethyl ester; With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 17h;

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield:

: 1055320-72-3
7-chloro-1H-indole-6-carboxylic acid

: 1055320-90-5
1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C

3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

3.2: 0.25 h

4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

6.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 - 120 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

7.2: 2.33 h / 20 - 200 °C / Microwave irradiation

8.1: methanol; hexane; benzene / 1.67 h / 20 °C

9.1: potassium trimethylsilonate / tetrahydrofuran / 17 h / 20 °C

With potassium trimethylsilonate; hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; cesium fluoride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; 20% Pd(OH)2 on carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;

Reference yield:

: 1055320-74-5
7-chloro-3-cyclohexyl-1H-indole-6-carboxylic acid

: 1055320-90-5
1-cyclohexyl-5,6-dihydro-2-phenyl-4H-pyrrolo[3,2,1-ij]quinoline-4,7-dicarboxylic acid, 7-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C

1.2: 0.25 h

2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 20 - 60 °C

4.1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 - 120 °C

5.1: sodium hydride / dimethyl sulfoxide / 0.17 h / 20 °C

5.2: 2.33 h / 20 - 200 °C / Microwave irradiation

6.1: methanol; hexane; benzene / 1.67 h / 20 °C

7.1: potassium trimethylsilonate / tetrahydrofuran / 17 h / 20 °C

With potassium trimethylsilonate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; cesium fluoride; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; toluene; benzene;