(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Base Information

Chemical Name:(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol
CAS No.:90367-62-7
Molecular Formula:C₃₅H₅₀O₄Si
Molecular Weight:562.865
Hs Code.:

(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Synonyms:(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Suppliers and Price of (1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

There total 21 articles about (1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-one

: 90410-99-4
(1S,4aS,7R,8R,8aR)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

: 90367-62-7
(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Guidance literature:: With L-Selectride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ja00325a017

Reference yield:

: 80106-30-5
(4E,6E)-octa-4,6-dien-1-ol

: 90367-62-7
(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Guidance literature:: Multi-step reaction with 17 steps

1: 95 percent / pyridine / 15 h / 5 °C

2: 94 percent / NaOMe / methanol / 2 h

3: 75 percent / 40 percent peracetic acid / ethyl acetate / 2 h / -20 - 0 °C

4: 70 percent / benzene / 24 h / 80 °C

5: 1 M lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 deg C, 5 d, -40 deg C, 8 h

7: aluminum amalgam / tetrahydrofuran; H₂O / 3 h

8: 92 percent / NaOMe / methanol / 24 h / 40 °C

9: 100 percent / TsOH / benzene / 72 h / 80 °C / Dean-Stark apparatus

10: 91 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

11: Me₃SiCl, NaI / acetonitrile / 1 h

12: benzene / 3 h / 80 °C / dark

13: 100 percent / BF₃*Et₂O / CH₂Cl₂ / 15 h

14: 1.) 1.6 M n-BuLi / 1.) THF, HMPA, 0 deg C, 30 min; 2.) THF, HMPA, -78 deg C to RT, 4 h

15: HgCl₂, CaCO₃ / acetonitrile; H₂O / 7 h / 80 °C

16: 6 percent sodium amalgam / methanol / 2 h

17: L-Selectride / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; peracetic acid; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; aluminium amalgam; boron trifluoride diethyl etherate; sodium methylate; L-Selectride; toluene-4-sulfonic acid; calcium carbonate; sodium iodide; mercury dichloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile; benzene;
DOI:10.1021/ja00325a017

Reference yield:

: 68823-50-7
methyl (4E,6E)-octa-4,6-dienoate

: 90367-62-7
(1S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

Guidance literature:: Multi-step reaction with 18 steps

1: 99 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: 95 percent / pyridine / 15 h / 5 °C

3: 94 percent / NaOMe / methanol / 2 h

4: 75 percent / 40 percent peracetic acid / ethyl acetate / 2 h / -20 - 0 °C

5: 70 percent / benzene / 24 h / 80 °C

6: 1 M lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 deg C, 5 d, -40 deg C, 8 h

8: aluminum amalgam / tetrahydrofuran; H₂O / 3 h

9: 92 percent / NaOMe / methanol / 24 h / 40 °C

10: 100 percent / TsOH / benzene / 72 h / 80 °C / Dean-Stark apparatus

11: 91 percent / LiAlH₄ / tetrahydrofuran / 2 h / Ambient temperature

12: Me₃SiCl, NaI / acetonitrile / 1 h

13: benzene / 3 h / 80 °C / dark

14: 100 percent / BF₃*Et₂O / CH₂Cl₂ / 15 h

15: 1.) 1.6 M n-BuLi / 1.) THF, HMPA, 0 deg C, 30 min; 2.) THF, HMPA, -78 deg C to RT, 4 h

16: HgCl₂, CaCO₃ / acetonitrile; H₂O / 7 h / 80 °C

17: 6 percent sodium amalgam / methanol / 2 h

18: L-Selectride / tetrahydrofuran / 0.5 h / 0 °C

With pyridine; peracetic acid; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; aluminium amalgam; boron trifluoride diethyl etherate; sodium methylate; L-Selectride; toluene-4-sulfonic acid; calcium carbonate; sodium iodide; mercury dichloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; acetonitrile; benzene;
DOI:10.1021/ja00325a017