(3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one

Base Information

• Chemical Name: (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one
• CAS No.: 213480-20-7
• Molecular Formula: C₂₃H₂₇NO₅
• Molecular Weight: 397.471
• Mol file: 213480-20-7.mol

Synonyms:(3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one

Chemical Property of (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one

There total 3 articles about (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3R,4S)-1-benzyl-4-[(1S,5S)-5-benzyloxymethyl-3,3-dimethyl-2,4-dioxacyclopentane-1-yl]-3-benzyloxyazetidin-2-one (190007-79-5) → (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one (213480-20-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 760 Torr;

DOI:10.1021/jo980354x

Reference yield:

(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde (81028-12-8) → (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one (213480-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 4A MS / CH₂Cl₂ / 1 h / 0 °C

2: 8.29 g / triethylamine / CH₂Cl₂ / -78 - 20 °C

3: 95 percent / hydrogen / Pd/C / methanol / 20 °C / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; 1: Condensation / 2: Cycloaddition / 3: Hydrogenolysis;

DOI:10.1021/jo980354x

Reference yield:

Benzyl-[1-((4S,5S)-5-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine → (3R,4S)-1-Benzyl-3-benzyloxy-4-((4S,5S)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one (213480-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 8.29 g / triethylamine / CH₂Cl₂ / -78 - 20 °C

2: 95 percent / hydrogen / Pd/C / methanol / 20 °C / 760 Torr

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; 1: Cycloaddition / 2: Hydrogenolysis;

DOI:10.1021/jo980354x

upstream raw materials:

(3R,4S)-1-benzyl-4-[(1S,5S)-5-benzyloxymethyl-3,3-dimethyl-2,4-dioxacyclopentane-1-yl]-3-benzyloxyazetidin-2-one

(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

Downstream raw materials:

(S)-2-[(S)-2-Benzylamino-2-((4S,5S)-5-carbamoyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetylamino]-3-phenyl-propionic acid benzyl ester

(S)-2-((2S,3S,4S)-2-Benzylamino-5-carbamoyloxy-3,4-dihydroxy-pentanoylamino)-4-methyl-pentanoic acid benzyl ester

(S)-2-[(S)-2-Benzylamino-2-((4S,5S)-5-carbamoyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-acetylamino]-4-methyl-pentanoic acid benzyl ester

Carbamic acid (4S,5S)-5-((2S,3R)-1-benzyl-3-benzyloxy-4-oxo-azetidin-2-yl)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester