190007-79-5Relevant academic research and scientific papers
Practical synthesis of α-amino acid N-carboxy anhydrides of polyhydroxylated α-amino acids from β-lactam frameworks. Model studies toward the synthesis of directly linked peptidyl nucleoside antibiotics
Palomo,Oiarbide,Esnal,Landa,Miranda,Linden
, p. 5838 - 5846 (2007/10/03)
A straightforward method for the synthesis of polyhydroxylated α-amino acid N-carboxy anhydrides (NCAs) is described as the means by which short peptide segments comprised of a polyhydroxylated chain are easily affordable. The entire sequence lies in the
Synthetic studies towards peptidyl nucleoside antibiotics: First synthesis of a polyoxamic acid derivative enabling direct coupling with α-amino acid esters
Palomo, Claudio,Oiarbide, Mikel,Esnal, Aitor
, p. 691 - 692 (2007/10/03)
The reaction of the Mukaiyama's aldehyde-derived N-benzyl imine with an hydroxyketene equivalent followed by exposure of the resulting α-hydroxy β-lactam to NaOCl and 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) provides a novel α-amino acid N-carboxy an
