2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER
• CAS No.: 100501-57-3
• Molecular Formula: C₁₂H₁₉N₃O₂
• Molecular Weight: 237.302
• Hs Code.: 2933990090
• Mol file: 100501-57-3.mol

Synonyms:5-Boc-2-Methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridine;

Chemical Property of 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER

Chemical Property:

• Refractive Index: 1.568
• Boiling Point: 360.1 °C at 760 mmHg
• Flash Point: 171.6 °C
• PSA: 47.36000
• Density: 1.18 g/cm³
• LogP: 1.65120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl2-methyl-6,7-dihydro-2H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER

There total 7 articles about 2-METHYL-2,4,6,7-TETRAHYDRO-5H-PYRAZOLO[4,3-C]PYRIDINE-5-CARBOXYLIC ACID, TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(2-methylhydrazono)piperidine-1-carboxylate (1430218-14-6) → tert-butyl 2-methyl-6,7-dihydro-2H-pyrazolo(4,3-c)pyridine-5(4H)-carboxylate (100501-57-3)

Guidance literature:

With N,N-dimethyl-formamide dimethyl acetal; In N,N-dimethyl-formamide; at 90 ℃; for 12h;

Reference yield:

1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester (230301-11-8,924869-27-2) + methyl iodide (74-88-4) → tert-butyl 2-methyl-6,7-dihydro-2H-pyrazolo(4,3-c)pyridine-5(4H)-carboxylate (100501-57-3) + tert-butyl 1-methyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

Guidance literature:

1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 2h;

methyl iodide; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield:

tert-butyl 4-(2-methylhydrazono)piperidine-1-carboxylate (1430218-14-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → tert-butyl 2-methyl-6,7-dihydro-2H-pyrazolo(4,3-c)pyridine-5(4H)-carboxylate (100501-57-3)

Guidance literature:

With trichlorophosphate; at -20 - 80 ℃; for 5h; regioselective reaction;

DOI:10.1016/j.tetlet.2014.02.058

upstream raw materials:

tert-butyl 4-(2-methylhydrazono)piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

N,N-dimethyl-formamide

3-dimethylaminomethylene-4-oxo-piperidine-1-carboxylic acid tert-butyl ester