methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

Base Information

Chemical Name:methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate
CAS No.:1356493-23-6
Molecular Formula:C₂₆H₂₄O₇
Molecular Weight:448.472
Hs Code.:

Synonyms:methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

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Chemical Property of methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

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Technology Process of methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

There total 4 articles about methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1356493-19-0
methyl 3-iodo-4-methoxy-2-(4-methoxyphenyl)benzofuran-6-carboxylate

: 192182-54-0
3,5-dimethoxyphenylboronic acid

: 1356493-23-6
methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

Guidance literature:: With trans-bis(triphenylphosphine)palladium dichloride; sodium hydrogencarbonate; In water; N,N-dimethyl-formamide; at 20 - 80 ℃; for 7.16667h;
DOI:10.1002/ejoc.201101422

Reference yield:

: 1356493-17-8
methyl 3,5-dimethoxy-4-(4-methoxyphenylethynyl)benzoate

: 1356493-23-6
methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine / dichloromethane / 19 h / 20 °C

2: trans-bis(triphenylphosphine)palladium dichloride; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 7.17 h / 20 - 80 °C

With trans-bis(triphenylphosphine)palladium dichloride; iodine; sodium hydrogencarbonate; In dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1002/ejoc.201101422

Reference yield:

: 65566-16-7
methyl 4-iodo-3,5-dimethoxybenzoate

: 1356493-23-6
methyl 3-(3,5-dimethoxyphenyl)-4-methoxy-2-(4-methoxyphenyl)-benzofuran-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; diisopropylamine / N,N-dimethyl acetamide / 3 h / 40 - 50 °C / Inert atmosphere

2: iodine / dichloromethane / 19 h / 20 °C

3: trans-bis(triphenylphosphine)palladium dichloride; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 7.17 h / 20 - 80 °C

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; iodine; sodium hydrogencarbonate; diisopropylamine; In dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; 1: Sonogashira coupling / 3: Suzuki coupling;
DOI:10.1002/ejoc.201101422