65566-16-7Relevant academic research and scientific papers
Total Synthesis of Isohericenone J via a Stille Coupling Reaction
Cao, Wei,Chen, Ping,Tang, Yu
, p. 1701 - 1705 (2020/06/08)
The first total synthesis of isohericenone J is reported. Key features of this synthetic strategy are a Friedel-Crafts reaction to construct the isobenzofuranone unit and a Pd-catalyzed Stille coupling reaction for the formation of the C5-C1′ bond, generating the natural product, as well as one of its isomers, in 6.0% overall yield in eight steps. This strategy provides a foundation for the synthesis of challenging isobenzofuranone and isoindolinone-type derivatives.
Design, synthesis, in vitro and in silico studies of 2, 3-diaryl benzofuran derivatives as antitubercular agents
Bhukya, Balakishan,Shukla, Aparna,Chaturvedi, Vinita,Trivedi, Priyanka,Kumar, Shailesh,Khan, Feroz,Negi, Arvind S.,Srivastava, Santosh Kumar
, (2020/05/01)
As a part of our drug discovery program for anti-tubercular agents, a total of seventeen 2, 3-diaryl benzofuran hybrids were designed, synthesized and screened for their anti-tubercular potential against Mycobacterium tuberculosis H37Ra avirulent strain. Out of seventeen, four derivatives showed significant activity against M. tuberculosis H37Ra avirulent strain (ATCC 25177) with MIC value ranging from 12.5 to 50 μg/mL but out of four, one derivative (9E) was significantly active (MIC 12.5 μg/mL), which was further supported by the molecular docking energy (?8.4 kcal/mol) with respect to the first line anti-tubercular drug, isoniazid (?6.2 kcal/mol) on the target Polyketide Synthase-13. All the derivatives were also evaluated for their cytotoxicity against the normal lung cell line L-132 by the MTT assay and no toxicity was observed up to 27.4 μg/mL concentration. This report on the antitubercular potential of benzofuran derivatives may be of great help in anti-tubercular drug development.
Catalytic, Diastereoselective 1,2-Difluorination of Alkenes
Banik, Steven M.,Medley, Jonathan William,Jacobsen, Eric N.
supporting information, p. 5000 - 5003 (2016/05/19)
We describe a direct, catalytic approach to the 1,2-difluorination of alkenes. The method utilizes a nucleophilic fluoride source and an oxidant in conjunction with an aryl iodide catalyst and is applicable to alkenes with all types of substitution patterns. In general, the vicinal difluoride products are produced with high diastereoselectivities. The observed sense of stereoinduction implicates anchimeric assistance pathways in reactions of alkenes bearing neighboring Lewis basic functionality.
Synthesis and tunable ion-recognition properties of novel macrocyclic triamides
Ge, Ziyi,Zhang, Xingye,Chen, Shaojie,Liu, Ying,Peng, Ruixiang,Yokazawa, Tsutomu
, p. 5730 - 5738 (2015/03/30)
In this work, we report synthesis of rigid macrocyclic triamides and their tunable ion-recognition properties as selective anion and metal receptors. Diphenylacetylene-containing cyclic triamide CTA-1b and three cyclic triamides bearing functional methoxy
An in situ acidic carbon dioxide/glycol system for aerobic oxidative iodination of electron-rich aromatics catalyzed by Fe(NO3)3·9H2O
Ma, Ran,Huang, Cheng-Bin,Liu, An-Hua,Li, Xue-Dong,He, Liang-Nian
, p. 4308 - 4312 (2015/01/08)
An environmentally benign CO2/glycol reversible acidic system was developed for the iron(iii)-catalyzed aerobic oxidative iodination of electron-rich aromatics without the need for any conventional acid additive or organic solvent. Notably, moderate to high isolated yields (up to 97%) of the aryl iodides were attained with comparable regioselectivity when ferric nitrate nonahydrate was used as the catalyst with molecular iodine under 1 MPa of CO2.
Concise total synthesis of permethylated anigopreissin a, a new benzofuryl resveratrol dimer
Chiummiento, Lucia,Funicello, Maria,Lopardo, Maria Teresa,Lupattelli, Paolo,Choppin, Sabine,Colobert, Francoise
experimental part, p. 188 - 192 (2012/01/15)
The versatile preparation of permethylated anigopreissin A (1) has been accomplished from methyl 3,5-dihydroxybenzoate. The key steps of the synthesis are sequential Sonogashira and Suzuki cross-couplings for the construction of the 2,3-diarylbenzo[b]furan moiety and Wittig olefination for the introduction of the styryl group.
Hydroxylated Long-Chain Resveratrol Derivatives Useful as Neurotrophic Agents
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Page/Page column 10, (2010/03/31)
The present invention relates to a compound of general formula (I) below in which R1, R2 and R3 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl group or a (C1-C6 alkyl)carbonyl group, R4, R5, R6 and R7 represent a hydrogen or a C1-C6 alkyl group, a C1-C6 alkoxy group or a (C1-C6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.
Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation
Hauss, Frederique,Liu, Jiawei,Michelucci, Alessandro,Coowar, Djalil,Morga, Eleonora,Heuschling, Paul,Luu, Bang
, p. 4218 - 4222 (2008/02/10)
The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.
