10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Base Information

Chemical Name:10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester
CAS No.:858132-14-6
Molecular Formula:C₃₇H₆₂N₆O₈
Molecular Weight:718.935
Hs Code.:

Synonyms:10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Suppliers and Price of 10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

There total 5 articles about 10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 858132-12-4
10-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-phenyl-propionyl}-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

: 858132-14-6
10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In acetonitrile; at 20 ℃; for 0.283333h;
DOI:10.1016/j.tet.2005.03.081

Reference yield:

: 858132-10-2
10-(2-amino-3-phenyl-propionyl)-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

: 858132-14-6
10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / HOAt; HATU; collidine / dimethylformamide; CH₂Cl₂ / 48 h / 40 °C

2: 85 percent / tetrabutylammonium fluoride trihydrate / acetonitrile / 0.28 h / 20 °C

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2005.03.081

Reference yield:

: 858132-08-8
10-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

: 858132-14-6
10-[2-(2-amino-3-methyl-butyrylamino)-3-phenyl-propionyl]-1,4,7,10-tetraazacyclododecan-1,4,7-tricarbonic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / tetrabutylammonium fluoride trihydrate / acetonitrile / 0.28 h / 20 °C

2: 85 percent / HOAt; HATU; collidine / dimethylformamide; CH₂Cl₂ / 48 h / 40 °C

3: 85 percent / tetrabutylammonium fluoride trihydrate / acetonitrile / 0.28 h / 20 °C

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; tetrabutyl ammonium fluoride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.tet.2005.03.081