(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

Base Information

Chemical Name:(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one
CAS No.:1355995-17-3
Molecular Formula:C₃₂H₂₉NO₈
Molecular Weight:555.584
Hs Code.:

Synonyms:(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

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Chemical Property of (3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

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Technology Process of (3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

There total 1 articles about (3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzoic acid (3aR,4R,5R,6aS)-4-((E)-3-hydroxy-5-phenyl-pent-1-enyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

: 122-04-3
4-nitro-benzoyl chloride

: 1355995-17-3
(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

: 1355995-24-2
(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

Guidance literature:: With dmap; triethylamine;

Reference yield:

: 1355995-17-3
(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

: 155206-00-1
bimatoprost

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; methanol / dichloromethane / 25 - 30 °C

1.2: pH 4

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 6 h / -80 - -76 °C

2.2: -80 - -76 °C

3.1: potassium tert-butylate / tetrahydrofuran / -12 - 10 °C

3.2: 12 h / 25 - 30 °C

3.3: 48 h / 25 - 30 °C

With methanol; potassium tert-butylate; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1355995-17-3
(3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one

: 145773-21-3
(1S,5R,6R,7R)-6-<(3R)-3-hydroxy-5-phenyl-1-pentyl>-7(R)-hydroxy-2-oxabicyclo<3.3.0>octan-3-one

Guidance literature:: (3aR,4R,5R,6aS)-4-[3S-(p-nitrobenzoyloxy)-5-phenyl-1E-pentenyl]-5-(benzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one; With methanol; potassium carbonate; In dichloromethane; at 25 - 30 ℃;

With hydrogenchloride; In dichloromethane; water; pH=4;