(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

Base Information

Chemical Name:(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid
CAS No.:1401463-55-5
Molecular Formula:C₃₀H₂₃N₃O₂S
Molecular Weight:489.598
Hs Code.:

Synonyms:(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

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Chemical Property of (2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

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Technology Process of (2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

There total 6 articles about (2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1416369-35-1
C₂₇H₂₂N₂OS

: 372-09-8
cyanoacetic acid

: 1401463-55-5
(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

Guidance literature:: With piperidine; In acetonitrile; at 80 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.dyepig.2012.09.001

Reference yield:

: 36448-60-9
2-methyl-1-thiophen-2-yl-propan-1-one

: 1401463-55-5
(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / 85 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / toluene / 24 h / 85 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 20 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: piperidine / acetonitrile / 3 h / 80 °C / Inert atmosphere

With piperidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; toluene-4-sulfonic acid; sodium t-butanolate; XPhos; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/j.dyepig.2012.09.001

Reference yield:

: 1416369-33-9
C₁₄H₁₂BrNS

: 1401463-55-5
(2E)-2-cyano-3-(5-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)thiophen-2-yl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / toluene / 24 h / 85 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: piperidine / acetonitrile / 3 h / 80 °C / Inert atmosphere

With piperidine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; sodium t-butanolate; XPhos; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1016/j.dyepig.2012.09.001