5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate

Base Information

• Chemical Name: 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate
• CAS No.: 89321-92-6
• Molecular Formula: C₃₇H₄₉N₃O₄
• Molecular Weight: 599.814

Synonyms:5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate

Chemical Property of 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate

There total 2 articles about 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Phenyl-1,2,4-triazolidine-3,5-dione (4233-33-4) + Δ5,7,9-cholestatrien-3β-ol acetate (1255-91-0) → 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate (89321-92-6)

Guidance literature:

In dichloromethane; acetone; at -10 ℃; for 0.25h;

DOI:10.1002/ejoc.200400117

Reference yield:

7-Dehydrocholesteryl acetate (1059-86-5) → 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate (89321-92-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / mercuric acetate; acetic acid / ethanol / 0.5 h / Heating

2: 75 percent / acetone; CH₂Cl₂ / 0.25 h / -10 °C

With mercury(II) diacetate; acetic acid; In ethanol; dichloromethane; acetone;

DOI:10.1002/ejoc.200400117

Reference yield: 50.0%

5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)cholesta-6,9(11)dien-3β-yl acetate (89321-92-6) → 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)-9α,11α-epoxycholest-6-en-3β-yl acetate (89321-93-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1002/ejoc.200400117

upstream raw materials:

4-Phenyl-1,2,4-triazolidine-3,5-dione

Δ^5,7,9-cholestatrien-3β-ol acetate

7-Dehydrocholesteryl acetate

Downstream raw materials:

5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolidine-1,2-diyl)-9α,11α-epoxycholest-6-en-3β-yl acetate

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