(S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

Base Information

Chemical Name:(S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide
CAS No.:1240523-67-4
Molecular Formula:C₂₅H₂₃N₅O₂S
Molecular Weight:457.556
Hs Code.:

Synonyms:(S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

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Chemical Property of (S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

There total 7 articles about (S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: (S)-3-(3-phenyl-2-(thiazol-5-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzoic acid

: 1240523-67-4
(S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

Guidance literature:: With ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 1240523-67-4
(S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 90 °C

2.1: sulfuric acid / toluene / Reflux

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

6.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 20 °C

7.1: dichloromethane / 1 h

7.2: 1 h / 20 °C

8.1: ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; sulfuric acid; water; hydrogen; sodium carbonate; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1214357-18-2
C₁₂H₈N₂O₄

: 1240523-67-4
(S)-3-(3-phenyl-2-(thiazol-4-ylmethylamino)propanamido)-5-(pyridin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / toluene / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

5.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 20 °C

6.1: dichloromethane / 1 h

6.2: 1 h / 20 °C

7.1: ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; sulfuric acid; water; hydrogen; ammonium chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;