Technology Process of 1-iodovinyl 3-(trifluoromethyl)phenylisopropylcarbamate
There total 4 articles about 1-iodovinyl 3-(trifluoromethyl)phenylisopropylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
vinyl 3-(trifluoromethyl)phenylisopropylcarbamate;
With
tert.-butyl lithium;
In
tetrahydrofuran;
at -78 ℃;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1021/ol2029355
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 4 h / 20 °C / Inert atmosphere
2.1: tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 - 20 °C / Inert atmosphere
With
tert.-butyl lithium;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;
DOI:10.1021/ol2029355
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 4 h / 20 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 4 h / 20 °C / Inert atmosphere
4.1: tert.-butyl lithium / tetrahydrofuran / -78 °C / Inert atmosphere
4.2: 0.5 h / -78 - 20 °C / Inert atmosphere
With
pyridine; tert.-butyl lithium; sodium tris(acetoxy)borohydride;
In
tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; acetic acid; 1,2-dichloro-ethane;
DOI:10.1021/ol2029355
