vinyl 3-(trifluoromethyl)phenylisopropylcarbamate

Base Information

• Chemical Name: vinyl 3-(trifluoromethyl)phenylisopropylcarbamate
• CAS No.: 1350911-15-7
• Molecular Formula: C₁₃H₁₄F₃NO₂
• Molecular Weight: 273.255
• Mol file: 1350911-15-7.mol

Synonyms:vinyl 3-(trifluoromethyl)phenylisopropylcarbamate

Chemical Property of vinyl 3-(trifluoromethyl)phenylisopropylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of vinyl 3-(trifluoromethyl)phenylisopropylcarbamate

There total 3 articles about vinyl 3-(trifluoromethyl)phenylisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-isopropyl-N-(3-trifluoromethylphenyl)carbamoylchloride + Lithium enolate of the acetaldehyde (675825-21-5) → vinyl 3-(trifluoromethyl)phenylisopropylcarbamate (1350911-15-7)

Guidance literature:

In 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol2029355

Reference yield:

3-trifluoromethylaniline (98-16-8) → vinyl 3-(trifluoromethyl)phenylisopropylcarbamate (1350911-15-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / acetic acid; 1,2-dichloro-ethane / 4 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 4 h / 20 °C / Inert atmosphere

With pyridine; sodium tris(acetoxy)borohydride; In 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; acetic acid; 1,2-dichloro-ethane;

DOI:10.1021/ol2029355

Reference yield:

(3-trifluoromethyl)-N-isopropylbenzenamine (65934-71-6) → vinyl 3-(trifluoromethyl)phenylisopropylcarbamate (1350911-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 4 h / 20 °C / Inert atmosphere

With pyridine; In 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane;

DOI:10.1021/ol2029355

upstream raw materials:

Lithium enolate of the acetaldehyde

3-trifluoromethylaniline

(3-trifluoromethyl)-N-isopropylbenzenamine

Downstream raw materials:

1-iodovinyl 3-(trifluoromethyl)phenylisopropylcarbamate

5,5-dimethylhex-1-en-3-yn-2-yl 3-(trifluoromethyl)phenylisopropylcarbamate

4-(3-(trifluoromethyl)phenyl)-2,7,7-trimethyloct-5-yn-4-ol

4-(3-(trifluoroethyl)phenyl)-2,2,7,7-tetramethyloct-5-yn-4-ol