2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

Base Information

Chemical Name:2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid
CAS No.:1258459-21-0
Molecular Formula:C₁₃H₁₁NO₄
Molecular Weight:245.235
Hs Code.:

Synonyms:2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

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Chemical Property of 2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

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Technology Process of 2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

There total 8 articles about 2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258459-20-9
2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid methyl ester

: 1258459-21-0
2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

Guidance literature:: 2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid methyl ester; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 39172-32-2
2-(3-bromophenyl)-2-methyl-[1,3]dioxolane

: 1258459-21-0
2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium phosphate monohydrate / palladium diacetate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine / toluene / 6 h / 90 - 100 °C / Inert atmosphere

2.1: sodium hydroxide; water / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: pH 5 - 6

3.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / 1.42 h / 0 °C / Inert atmosphere; Reflux

5.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

6.1: hydrogenchloride; water / tetrahydrofuran / 20 °C / Inert atmosphere

7.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; potassium phosphate monohydrate; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; hexamethylenetetramine; water; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(ll) bromide; palladium diacetate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1258459-21-0
2-(3-acetyl-benzyl)-oxazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium tetrafluoroborate / ethylene glycol / 3.5 h / 95 °C / Inert atmosphere

2.1: potassium phosphate monohydrate / palladium diacetate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine / toluene / 6 h / 90 - 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / tetrahydrofuran / 20 °C / Inert atmosphere

3.2: pH 5 - 6

4.1: dmap; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: methoxycarbonylsulfamoyl-triethylammmonium hydroxide / tetrahydrofuran / 1.42 h / 0 °C / Inert atmosphere; Reflux

6.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: sodium hydroxide; water / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; lithium tetrafluoroborate; potassium phosphate monohydrate; methoxycarbonylsulfamoyl-triethylammmonium hydroxide; hexamethylenetetramine; water; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; copper(ll) bromide; palladium diacetate; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; In tetrahydrofuran; dichloromethane; ethylene glycol; toluene;