39172-32-2

Basic information

• Product Name: 2-(3-bromophenyl)-2-methyl-1,3-dioxolane
• Synonyms: 2-(3-bromophenyl)-2-methyl-1,3-dioxolane
• CAS NO: 39172-32-2
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.1
• Mol File: 39172-32-2.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 294.764°C at 760 mmHg
• Flash Point: 130.195°C
• Appearance: /
• Density: 1.433g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.547
• CAS DataBase Reference: 2-(3-bromophenyl)-2-methyl-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-bromophenyl)-2-methyl-1,3-dioxolane(39172-32-2)
• EPA Substance Registry System: 2-(3-bromophenyl)-2-methyl-1,3-dioxolane(39172-32-2)

Safety Data

• Hazardous Substances Data: 39172-32-2(Hazardous Substances Data)

Usage

Type of compound

Brominated derivative of dioxolane (a cyclic ether compound)

Uses

Intermediate in the synthesis of various compounds used in pharmaceutical and pesticide products; building block in organic synthesis and chemical research

Unique property

Presence of the bromine atom, which gives it unique reactivity and properties valuable in the development of new materials and substances.

InChI:InChI=1/C10H11BrO2/c1-10(12-5-6-13-10)8-3-2-4-9(11)7-8/h2-4,7H,5-6H2,1H3

Upstream product

• 107-21-1 ethylene glycol 
• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 64999-99-1 1-(3-deuterio-phenyl)-ethanone 
• 203443-01-0 6-methoxy-2-[3-(2-methyl-1,3-dioxolan-2-yl)phenyl]-3,4-dihydronaphthalene 
• 132100-31-3 3-(2-methyl-[1,3]dioxolan-2-yl)benzaldehyde 
• 60283-15-0 1-(3-acetylphenyl)-2,2,2-trifluoroethan-1-one 
• 864147-97-7 1-[3-(2-methyl-3-phenyl-allyl)-phenyl]-ethanone 
• 203443-13-4 6-Methoxy-2-[3-(2-methyl-[1,3]dioxolan-2-yl)-benzyl]-1,2,3,4-tetrahydro-naphthalen-1-ol 
• 203443-11-2 6-Methoxy-2-[3-(2-methyl-[1,3]dioxolan-2-yl)-benzyl]-3,4-dihydro-2H-naphthalen-1-one 
• 126030-91-9 2-(3-trimethylgermylphenyl)-2-methyl-1,3-dioxolane 
• 1357108-53-2 (3-(2-methyl-1,3-dioxolan-2-yl)phenyl)(diphenyl)methanol 
• 1357107-94-8 (R)-3-(((3-acetylphenyl)diphenylmethyl)sulfanyl)2-aminopropanoic acid 
• 18749-47-8 3-carboxymethylacetophenone 
• 1258459-15-2 [3-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-acetic acid 

Relevant articles and documents

Chemo- and Stereoselective Synthesis of Fluorinated Amino Alcohols through One-pot Reactions using Alcohol Dehydrogenases and Amine Transaminases

A series of amino alcohols have been prepared in a chemo-, diastereo- and enantioselective fashion starting from the corresponding (het)aryl diketones, avoiding tedious chemical protection and deprotection steps. Different alcohol dehydrogenases have been

Stereoselective Bioreduction of Telluro-Acetophenones to Optically Active Hydroxy Tellurides

Organotellurium compounds exhibit a broad range of useful applications in organic synthesis, materials science and medicinal chemistry fields. Despite their increasing applicability, the synthesis of enantiomerically pure organotellurium compounds remains nowadays scarcely reported in the literature. Herein, the chemical synthesis and biocatalyzed reductions of a set of telluro-acetophenones using both (R) and (S)-selective alcohol dehydrogenases (ADHs) is described for the first time, obtaining enantiomerically enriched hydroxy tellurides with excellent selectivities under very mild reaction conditions. On the one hand, enantiopure para-substituted (S)-hydroxy tellurides were obtained using the Ras-ADH (77–95 % conversion) and ADH-A (52–75 %), the ADH-A leading to the enantiopure (S)-hydroxy tellurides substituted at the meta-position (69–75 %). On the other hand, the evo-1.1.200 displayed high selectivity towards the preparation of optically alcohols with substitutions at the para-position of the aromatic ring (60–68 % conversion and 92–97 % ee), while the Lb-ADH led to the best results when reducing bulky ketones at the meta-position (79–82% conversion and 88–99 % ee).

Diacetal Ditellurides as Highly Active and Selective Antiparasitic Agents toward Leishmania amazonensis

Leishmaniasis is a neglected tropical disease and a public health concern in at least 98 countries, affecting mainly the poorest populations. Pharmaceuticals and chemotherapies available for leishmaniasis treatment have several limitations, which clearly justify the efforts to find new potential antileishmanial drugs. In this context, antiprotozoal activities toward different Leishmania species have been reported for hypervalent tellurium compounds, which motivated us to investigate, for the first time, the leishmanicidal properties of some nonhypervalent diaryl ditellurides. Thus, this work describes in vitro activity against Leishmania amazonensis and the cytotoxicities of diaryl ditellurides. Ditelluride LQ7 revealed a strong leishmanicidal activity on promastigotes and amastigotes at submicromolar levels (IC50 = 0.9 ± 0.1 and 0.5 ± 0.1 μmol L-1, respectively) and presented selectivity indexes greater than those of reference drug miltefosine. This preliminary study suggests that diaryl ditellurides may be promising scaffolds for the development of new agents for leishmaniasis treatment.