phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

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Chemical Name:phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester
CAS No.:749254-11-3
Molecular Formula:C₄₇H₅₆N₂O₁₀Si
Molecular Weight:837.055
Hs Code.:

phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl}-ethyl ester

Synonyms:phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

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Chemical Property of phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

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Technology Process of phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

There total 1 articles about phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 39257-73-3
2-iodoethyl phenoxyacetate

: 80971-33-1
5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyldimethylsilyl)-2'-deoxythymidine

: 749254-11-3
phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 24h;
DOI:10.1021/ja0498540

Reference yield:

: 749254-11-3
phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

: 916853-14-0
1-[3-O-(tert-butyldimethylsilyl)-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl]-3-(2-hydroxyethyl)thymine

Guidance literature:: With propylamine; In dichloromethane; for 24h;
DOI:10.1021/ja0498540

Reference yield:

: 749254-11-3
phenoxy-acetic acid 2-{3-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-ethyl ester

: 749254-17-9
1-[5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-3-(2-iodo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: propylamine / CH₂Cl₂ / 24 h

2: 4.42 g / imidazole; PPh₃; I₂ / tetrahydrofuran / 3 h / 0 °C

With 1H-imidazole; propylamine; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0498540