N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

Base Information

Chemical Name:N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine
CAS No.:1350648-68-8
Molecular Formula:C₂₃H₂₅F₂N₅OSi
Molecular Weight:453.567
Hs Code.:

Synonyms:N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Chemical Property of N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

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Technology Process of N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

There total 4 articles about N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350648-20-2
7-iodo-1H-pyrazolo[4,3-b]pyridine

: 1350649-29-4
2-(2,5-difluorophenyl)pyridin-4-amine

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1350648-68-8
N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

: 1350648-67-7
N-(2-(2,5-difluorophenyl)pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: 7-iodo-1H-pyrazolo[4,3-b]pyridine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

2-(2,5-difluorophenyl)pyridin-4-amine; With (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate; palladium diacetate; In toluene; at 100 ℃; Inert atmosphere;

Reference yield:

: 97509-75-6
3-fluoropicolinonitrile

: 1350648-68-8
N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

: 1350648-67-7
N-(2-(2,5-difluorophenyl)pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

1.2: 0.67 h / -78 °C

2.1: hydrazine hydrate / butan-1-ol / 2 h / 105 °C

3.1: sodium nitrite; acetic acid / water / 25 h / 0 - 20 °C

3.2: 3 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

4.2: 2 h / 20 °C

4.3: 100 °C / Inert atmosphere

With n-butyllithium; sodium hydride; hydrazine hydrate; acetic acid; diisopropylamine; sodium nitrite; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 669066-35-7
3-fluoro-4-iodo-2-pyridinecarbonitrile

: 1350648-68-8
N-(2-(2,5-difluorophenyl)pyridin-4-yl)-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-pyrazolo[4,3-b]pyridin-7-amine

: 1350648-67-7
N-(2-(2,5-difluorophenyl)pyridin-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazolo[4,3-b]pyridin-7-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / butan-1-ol / 2 h / 105 °C

2.1: sodium nitrite; acetic acid / water / 25 h / 0 - 20 °C

2.2: 3 h / 80 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C

3.2: 2 h / 20 °C

3.3: 100 °C / Inert atmosphere

With sodium hydride; hydrazine hydrate; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide; butan-1-ol;