Technology Process of 1-(5-Amino-3-cyclopropylphenyl)-4-methyl-1H-tetrazol-5(4H)-one
There total 6 articles about 1-(5-Amino-3-cyclopropylphenyl)-4-methyl-1H-tetrazol-5(4H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(3-Cyclopropyl-5-nitrophenyl)-4-methyl-1H-tetrazol-5(4H)-one;
With
hydrogenchloride; tin(II) chloride dihdyrate;
In
ethanol; water;
at 80 ℃;
for 1h;
With
potassium carbonate;
In
water; ethyl acetate;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: caesium carbonate / tricyclohexylphosphine; palladium diacetate / toluene; water / 100 °C / Inert atmosphere
2: diammonium sulfide / ethanol; water / 1 h / 80 °C
3: toluene / 2 h / 100 °C
4: trimethylsilylazide / 100 °C
5: potassium carbonate / N,N-dimethyl-formamide / 20 °C
6: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 1 h / 80 °C
With
hydrogenchloride; diammonium sulfide; tin(II) chloride dihdyrate; trimethylsilylazide; potassium carbonate; caesium carbonate;
palladium diacetate; tricyclohexylphosphine;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diammonium sulfide / ethanol; water / 1 h / 80 °C
2: toluene / 2 h / 100 °C
3: trimethylsilylazide / 100 °C
4: potassium carbonate / N,N-dimethyl-formamide / 20 °C
5: hydrogenchloride; tin(II) chloride dihdyrate / ethanol; water / 1 h / 80 °C
With
hydrogenchloride; diammonium sulfide; tin(II) chloride dihdyrate; trimethylsilylazide; potassium carbonate;
In
ethanol; water; N,N-dimethyl-formamide; toluene;
