4-(2-(Piperidin-1-YL)ethoxy)phenol

Base Information

• Chemical Name: 4-(2-(Piperidin-1-YL)ethoxy)phenol
• CAS No.: 100238-42-4
• Molecular Formula: C13H19 N O2
• Molecular Weight: 221.299
• European Community (EC) Number: 600-042-5,926-878-3
• DSSTox Substance ID: DTXSID30442454
• Nikkaji Number: J2.442.965B
• Wikidata: Q82259737
• Mol file: 100238-42-4.mol

Synonyms:100238-42-4;4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENOL;4-[2-(1-Piperidinyl)ethoxy] phenol;4-(2-piperidin-1-ylethoxy)phenol;Phenol, 4-[2-(1-piperidinyl)ethoxy]-;4-[2-(Piperidin-1-yl)ethoxy]phenol;4-(2-(1-piperidinyl)ethoxy)-phenol;4-(2-(1-piperidinyl)ethoxy]-phenol;4-(2-piperidinoethoxy)phenol;SCHEMBL699174;DTXSID30442454;XGMJHNYRDUELOH-UHFFFAOYSA-N;4-(2-piperidin-1-yl-ethoxy)phenol;4-(2-Piperidin-1-yl-ethoxy)-phenol;AKOS009314928;4-(2-(1-piperidinyl) ethoxy)-phenol;AB24954;AC-13543;AS-62515;CS-0492194;FT-0765406;EN300-58636

Chemical Property of 4-(2-(Piperidin-1-YL)ethoxy)phenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 372.7°Cat760mmHg
• PKA: 10.31±0.15(Predicted)
• Flash Point: 179.2°C
• PSA: 32.70000
• Density: 1.096g/cm³
• LogP: 2.19480
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 221.141578849
• Heavy Atom Count: 16
• Complexity: 184

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(Ethanesulphonyl)piperazine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)O

Technology Process of 4-(2-(Piperidin-1-YL)ethoxy)phenol

There total 13 articles about 4-(2-(Piperidin-1-YL)ethoxy)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-[2-(4-benzyloxyphenoxy)ethyl]piperidine (182133-34-2) → 4-(2-piperidin-1-yl-ethoxy)-phenol (100238-42-4)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 20h; under 2068.65 Torr;

Reference yield: 58.0%

1-(2-(4-((tetrahydro-2H-pyran-2-yl)oxy)phenoxy)ethyl)piperidine → 4-(2-piperidin-1-yl-ethoxy)-phenol (100238-42-4)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b01580

Reference yield: 44.2%

C15H23NO3 → 4-(2-piperidin-1-yl-ethoxy)-phenol (100238-42-4)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2017.09.015

upstream raw materials:

piperidine

4-(2-bromoethoxy)-phenol

1-[2-(4-benzyloxyphenoxy)ethyl]piperidine

2-(piperidin-4-yl)ethyl chloride

Downstream raw materials:

6-methoxy-3-{4-[2-(1-piperidinyl)ethoxy]phenoxy}-2-(4-bromophenyl)benzo[b]thiophene S-oxide

6-methoxy-1-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalene-2-ol

1-(2-{4-[2-(4-fluorophenyl)-6-methoxynaphthalen-1-yloxy]phenoxy}ethyl)piperidine

6-(4-fluorophenyl)-5-[4-(2-piperidin-1-ylethoxy)phenoxy]naphthalen-2-ol

Refernces

• 1、 -. "BENZOTHIOPHENE ESTROGEN RECEPTOR MODULATORS". Paragraph 0629-0630. . Retrieved 2018/08/29.
• 2、 -. "LTA4H modulators and uses thereof". Page/Page column 30. . Retrieved 2008/12/07.