Technology Process of (8R,E)-8-azido-2,2,3,3,12,12-hexamethyl-11,11-diphenyl-4,10-dioxa-3,11-disilatridec-5-ene
There total 10 articles about (8R,E)-8-azido-2,2,3,3,12,12-hexamethyl-11,11-diphenyl-4,10-dioxa-3,11-disilatridec-5-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1039/b611121a
- Guidance literature:
-
Multi-step reaction with 7 steps
1: AcOH / H2O / 18 h / 20 °C
2: 7.40 g / Et3N / DMAP / CH2Cl2 / 12 h / 20 °C
3: Et3N / Me3N*HCl / toluene / 0.08 h / -30 °C
4: 7.42 g / NaN3 / dimethylformamide / 3.5 h / 65 °C
5: 87 percent / KOH / methanol / 2.5 h / -15 °C
6: 92 percent / aq. NaHCO3; KBr; TBAB / TEMPO; NaClO / CH2Cl2 / 0.08 h
7: 68 percent / DBU / CH2Cl2 / 1 h / 20 °C
With
potassium hydroxide; sodium azide; tetrabutylammomium bromide; sodium hydrogencarbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium bromide;
dmap; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; trimethylamine hydrochloride;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b611121a
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 92 percent / aq. NaHCO3; KBr; TBAB / TEMPO; NaClO / CH2Cl2 / 0.08 h
2: 68 percent / DBU / CH2Cl2 / 1 h / 20 °C
With
tetrabutylammomium bromide; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium bromide;
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite;
In
dichloromethane;
DOI:10.1039/b611121a
