4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

Base Information

Chemical Name:4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol
CAS No.:197297-82-8
Molecular Formula:C₁₉H₃₄O₃Si
Molecular Weight:338.563
Hs Code.:

Synonyms:4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

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Chemical Property of 4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

Chemical Property:

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Technology Process of 4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

There total 5 articles about 4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 197297-77-1
4-(2,5-dimethoxy-3,4,6-trimethylphenyl)butan-2-one

: 13170-43-9
(trimethylsilyl)methylmagnesium chloride

: 197297-82-8
4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

Guidance literature:: In tetrahydrofuran;
DOI:10.1055/s-1997-1522

Reference yield:

: 131426-03-4
1-iodo-2,5-bis(methoxy)-3,4,6-trimethylbenzene

: 197297-82-8
4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / CuI, NHEt₂ / PdCl₂(PPh₃)2 / 4 h / 45 °C

2: 96 percent / H₂ / PtO₂ / methanol / 2280 Torr

3: 89 percent / Dess-Martin periodinane / CH₂Cl₂

4: 1.) Mg, I₂ / 1.) Et₂O, 30 min, rt; 2.) Et₂O, reflux, 2 h

With copper(l) iodide; hydrogen; iodine; Dess-Martin periodane; magnesium; diethylamine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; dichloromethane;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<1075::AID-EJOC1075>3.0.CO;2-I

Reference yield:

: 197297-75-9
4-(2,5-dimethoxy-3,4,6-trimethylphenyl)but-3-yn-2-ol

: 197297-82-8
4-(2,5-dimethoxy-3,4,6-trimethylphenyl)-2-methyl-1-trimethylsilylbutan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / H₂ / PtO₂ / methanol / 2280 Torr

2: 89 percent / Dess-Martin periodinane / CH₂Cl₂

3: 1.) Mg, I₂ / 1.) Et₂O, 30 min, rt; 2.) Et₂O, reflux, 2 h

With hydrogen; iodine; Dess-Martin periodane; magnesium; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1002/(SICI)1099-0690(199905)1999:5<1075::AID-EJOC1075>3.0.CO;2-I