ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

Base Information

Chemical Name:ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate
CAS No.:781642-75-9
Molecular Formula:C₁₈H₁₈N₄O₆S
Molecular Weight:418.43
Hs Code.:

Synonyms:ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

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Chemical Property of ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

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Technology Process of ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

There total 7 articles about ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 70-23-5
ethyl Bromopyruvate

: 781642-73-7
2,5-anhydro-3-azido-6-O-benzoyl-3-deoxy-D-allonothioamide

: 781642-75-9
ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

Guidance literature:: In ethanol; at 80 ℃; for 0.833333h;
DOI:10.1016/j.ejmech.2016.01.037

Reference yield: 57.0%

: 70-23-5
ethyl Bromopyruvate

: 781642-73-7
2,5-anhydro-3-azido-6-O-benzoyl-3-deoxy-D-allonothioamide

: 60084-12-0
2-(4-carboethoxythiazol-2-yl)-5-((benzoyloxy)methyl)furan

: 781642-75-9
ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

Guidance literature:: In ethanol; for 0.833333h; Heating;
DOI:10.1016/j.tetlet.2004.07.104

Reference yield:

: 228399-09-5
2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allose ethylene acetal

: 781642-75-9
ethyl 2-(2-azido-5-O-benzoyl-2-deoxy-β-D-ribofuranosyl)thiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: TFA; aq. HCl / 72 h / 4 °C

2: NH₂OH*HCl; NaOAc / ethanol; CH₂Cl₂ / 2 h / 20 °C

3: MsCl; pyridine / 2.5 h / -15 - 20 °C

4: 34 percent / H₂S; pyridine / 2 h / 20 °C

5: 67 percent / TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

6: 57 percent / ethanol / 0.83 h / Heating

With pyridine; hydrogenchloride; hydrogen sulfide; hydroxylamine hydrochloride; sodium acetate; titanium tetrachloride; methanesulfonyl chloride; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1016/j.tetlet.2004.07.104