60084-12-0

Basic information

• Product Name: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate
• CAS NO: 60084-12-0
• Molecular Formula: C₁₈H₁₅NO₅S
• Molecular Weight: 357.3804
• Mol File: 60084-12-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 514.4°C at 760 mmHg
• Flash Point: 264.9°C
• Density: 1.308g/cm³
• Vapor Pressure: 1.08E-10mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate(60084-12-0)
• EPA Substance Registry System: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate(60084-12-0)

Safety Data

• Hazardous Substances Data: 60084-12-0(Hazardous Substances Data)

Upstream product

• 57944-12-4 5-benzoyloxymethyl-furan-2-carbothioic acid amide 
• 70-23-5 ethyl Bromopyruvate 
• 57944-10-2 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonthioamide 
• 615249-45-1 C₂₀H₁₈FNO₅S 
• 781642-73-7 2,5-anhydro-3-azido-6-O-benzoyl-3-deoxy-D-allonothioamide 
• 948040-42-4 2,5-anhydro-4,6-di-O-benzoyl-3-O-methanesulfonyl-D-gluconothioamide 
• 1188366-53-1 C₂₆H₂₇NO₁₀S₂ 
• 23316-67-8 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile 
• 781642-72-6 2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allonothioamide 
• 781642-71-5 2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allononitrile 
• 228399-09-5 2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allose ethylene acetal 
• 157506-37-1 2,5-anhydro-4,6-di-O-benzoyl-3-O-methanesulfonyl-D-glucose ethylene acetal 
• 948040-41-3 2,5-anhydro-4,6-di-O-benzoyl-3-O-methanesulfonyl-D-glucononitrile 
• 948040-40-2 C₂₁H₂₁NO₉S 

Downstream Products

• 60084-14-2 2-(5'-Hydroxymethylfuran-2'-yl)thiazole-4-carboxamide 

Relevant articles and documents

Synthesis of highly cytotoxic tiazofurin mimics bearing a 2,3-anhydro function in the furanose ring

This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-β-d-ribofuranosyl)thiazole-4-carboxamide (2′,3′-anhydro-tiazofurin) and the corresponding α- and β-homo-C-nucleosides. The synthetic approach was based on a multistep transformation of d-glucose into suitably protected aldonthioamides followed by their subsequent cyclocondensation with ethyl bromopyruvate to form the thiazole ring. Antiproliferative activity of the target molecules is reported against several human tumour cell lines.

Synthesis and biological evaluation of two novel 2′-substituted tiazofurin analogues

Two novel tiazofurin analogues, 2-(2-benzamido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 4 and 2-(2-azido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 5, have been synthesized starting from d-glucose and evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.

A new synthetic methodology for tiazofurin

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