60084-12-0

Basic information

• Product Name: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate
• CAS NO: 60084-12-0
• Molecular Formula: C₁₈H₁₅NO₅S
• Molecular Weight: 357.3804
• Mol File: 60084-12-0.mol

Chemical Properties

• Boiling Point: 514.4°C at 760 mmHg
• Flash Point: 264.9°C
• Density: 1.308g/cm³
• Vapor Pressure: 1.08E-10mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate(60084-12-0)
• EPA Substance Registry System: ethyl 2-{5-[(benzoyloxy)methyl]furan-2-yl}-1,3-thiazole-4-carboxylate(60084-12-0)

Safety Data

• Hazardous Substances Data: 60084-12-0(Hazardous Substances Data)

Upstream product

• 57944-12-4 5-benzoyloxymethyl-furan-2-carbothioic acid amide 
• 70-23-5 ethyl Bromopyruvate 
• 57944-10-2 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonthioamide 
• 1188366-53-1 C₂₆H₂₇NO₁₀S₂ 
• 23316-67-8 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile 
• 228399-06-2 C₂₃H₂₁F₃O₁₀S 
• 228399-14-2 C₂₂H₂₁FO₇ 
• 615249-43-9 C₂₀H₁₈FNO₆ 
• 615249-44-0 C₂₀H₁₆FNO₅ 
• 615249-42-8 C₂₀H₁₇FO₆ 
• 228399-00-6 2,5-anhydro-3,6-di-O-benzoyl-D-allose ethylene acetal 
• 781642-72-6 2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allonothioamide 
• 781642-71-5 2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allononitrile 
• 228399-09-5 2,5-anhydro-3-azido-6-O-benzoyl-4-O-benzyl-3-deoxy-D-allose ethylene acetal 

Downstream Products

• 60084-14-2 2-(5'-Hydroxymethylfuran-2'-yl)thiazole-4-carboxamide 

Relevant articles and documents

Synthesis of highly cytotoxic tiazofurin mimics bearing a 2,3-anhydro function in the furanose ring

This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-β-d-ribofuranosyl)thiazole-4-carboxamide (2′,3′-anhydro-tiazofurin) and the corresponding α- and β-homo-C-nucleosides. The synthetic approach was based on a multistep transformation of d-glucose into suitably protected aldonthioamides followed by their subsequent cyclocondensation with ethyl bromopyruvate to form the thiazole ring. Antiproliferative activity of the target molecules is reported against several human tumour cell lines.

Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring

This paper describes a divergent de novo synthesis of 2-(2,3-anhydro-β-dribofuranosyl)thiazole-4-carboxamide (2′,3′-anhydro-tiazofurin) and the corresponding α- and β-homo-C-nucleosides, as well as evaluation of their antitumour activities in vitro.

Synthesis and biological evaluation of two novel 2′-substituted tiazofurin analogues

Two novel tiazofurin analogues, 2-(2-benzamido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 4 and 2-(2-azido-2-deoxy-β-d- ribofuranosyl)thiazole-4-carboxamide 5, have been synthesized starting from d-glucose and evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.

De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties

A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-β-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-β-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside a

Synthesis and antiviral activity of certain thiazole C nucleosides

A general reaction of glycosyl cyanides with liquid hydrogen sulfide in the presence of 4 dimethylaminopyridine to provide the corresponding glycosylthiocarboxamides is described. These glycosylthiocarboxamides were utilized as the precursors for the synt