methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate
CAS No.:1263099-25-7
Molecular Formula:C₂₄H₃₃NO₄S
Molecular Weight:431.596
Hs Code.:

Synonyms:methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

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Chemical Property of methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

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Technology Process of methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

There total 5 articles about methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1263099-23-5
methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

: 1263099-25-7
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/jm401420j

Reference yield:

: 1263099-21-3
methyl 3-amino-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylate hydrochloride salt

: 1263099-25-7
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 5 h / 100 °C

3: boron tribromide / dichloromethane / 0.25 h / 0 °C

With boron tribromide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm401420j

Reference yield:

: 1263099-22-4
methyl 3-(3-(benzyloxy)cyclobutylamino)-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylate

: 1263099-25-7
methyl 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4R)-N-((1s,3S)-3-hydroxycyclobutyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 5 h / 100 °C

2: boron tribromide / dichloromethane / 0.25 h / 0 °C

With boron tribromide; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm401420j