methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

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Chemical Name:methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate
CAS No.:1263099-23-5
Molecular Formula:C₃₁H₃₉NO₄S
Molecular Weight:521.721
Hs Code.:

Synonyms:methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

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Chemical Property of methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

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Technology Process of methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

There total 3 articles about methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1263099-22-4
methyl 3-(3-(benzyloxy)cyclobutylamino)-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylate

: 55930-23-9
trans-4-methylcyclohexanecarbonyl chloride

: 1263099-23-5
methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

: 1263099-24-6
methyl trans-3-[(3-benzyloxy-cyclobutyl)-(4-methyl-cyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 100 ℃; for 5h;
DOI:10.1021/jm401420j

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1263099-23-5
methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

: 1263099-24-6
methyl trans-3-[(3-benzyloxy-cyclobutyl)-(4-methyl-cyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 5 h / 100 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401420j

Reference yield:

: 1263099-21-3
methyl 3-amino-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylate hydrochloride salt

: 30830-27-4
3-benzyloxy cyclobutanone

: 1263099-23-5
methyl cis-3-[(3-benzyloxy-cyclobutyl)-(4-methylcyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

: 1263099-24-6
methyl trans-3-[(3-benzyloxy-cyclobutyl)-(4-methyl-cyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 5 h / 100 °C

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm401420j