(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline
CAS No.:1402568-43-7
Molecular Formula:C₁₅H₁₄FN
Molecular Weight:227.281
Hs Code.:

Synonyms:(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Suppliers and Price of (±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

There total 5 articles about (±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 323-91-1
2-(4-fluoro-phenyl)-quinoline

: 1402568-43-7
(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium iodide; at 40 ℃; for 48h;
DOI:10.1002/chem.201201517

Reference yield: 57.0%

: 403-42-9
1-(4-fluorophenyl)ethanone

: 552-89-6
2-nitro-benzaldehyde

: 1402568-43-7
(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: 1-(4-fluorophenyl)ethanone; 2-nitro-benzaldehyde; In toluene; at 80 ℃; for 5h;

With hydrogen; In toluene; at 80 ℃; for 19h; under 5175.52 Torr;
DOI:10.1039/d1cy00418b

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1402568-43-7
(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / Inert atmosphere; Reflux

2: acetic acid; sodium cyanoborohydride / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; sodium carbonate; acetic acid; In 1,4-dioxane; water;
DOI:10.1021/ja4082827