2-(4-FLUOROPHENYL)QUINOLINE

Base Information

• Chemical Name: 2-(4-FLUOROPHENYL)QUINOLINE
• CAS No.: 323-91-1
• Molecular Formula: C15H10FN
• Molecular Weight: 223.25
• Mol file: 323-91-1.mol

Synonyms:2-(4-fluorophenyl)quinoline;2-(p-fluorophenyl)quinoline;2-(4-fluorophenyl)-quinoline;2-(4-Fluor-phenyl)-chinolin;2-(4-Fluoro-phenyl)-quinoline;

Chemical Property of 2-(4-FLUOROPHENYL)QUINOLINE

Chemical Property:

• PSA: 12.89000
• LogP: 4.04090

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-FLUOROPHENYL)QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROPHENYL)QUINOLINE

There total 62 articles about 2-(4-FLUOROPHENYL)QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-Aminobenzyl alcohol (5344-90-1) + 1-(4-Fluorophenyl)ethanol (403-41-8) → 2-(4-fluoro-phenyl)-quinoline (323-91-1)

Guidance literature:

With C₂₂H₂₄ClIrN₃O⁽¹⁺⁾*Cl^(1-); potassium hydroxide; In water; at 120 ℃; for 24h; Green chemistry;

DOI:10.1016/j.jcat.2019.03.028

Reference yield: 97.0%

2-Aminobenzyl alcohol (5344-90-1) + 1-(4-fluorophenyl)ethanone (403-42-9) → 2-(4-fluoro-phenyl)-quinoline (323-91-1)

Guidance literature:

With potassium hydroxide; Grubbs catalyst first generation; In 1,4-dioxane; at 80 ℃; for 1h;

DOI:10.1039/b109245f

Reference yield: 96.0%

(E)-3-(2-aminophenyl)-1-(4-fluorophenyl)prop-2-en-1-one → 2-(4-fluoro-phenyl)-quinoline (323-91-1)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In 1,2-dichloro-ethane; at 80 ℃; for 11h;

DOI:10.1021/acs.joc.8b00552

upstream raw materials:

2-(4-fluorophenyl)-quinoline-4-carboxylic acid

2-Aminobenzyl alcohol

1-(4-fluorophenyl)ethanone

1-(4-Fluorophenyl)ethanol

Downstream raw materials:

(S)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline(S)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

(R)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

(±)-2-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline

2-(4-fluorophenyl)-4-methylquinoline

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