acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Base Information

Chemical Name:acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester
CAS No.:745809-51-2
Molecular Formula:C₃₂H₄₄O₉Si
Molecular Weight:600.781
Hs Code.:

acetic acid 3-[1-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Synonyms:acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Suppliers and Price of acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

There total 9 articles about acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 745809-50-1
1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

: 745809-51-2
acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Guidance literature:: 1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene; pentacarbonyl{1-[2,5-bis(methoxymethoxy)phenyl]-1-methoxymethylidene}chromium; In tetrahydrofuran; at 54 ℃; for 14h;

With air; In tetrahydrofuran; diethyl ether; for 0.25h;
DOI:10.1021/jo049426c

Reference yield:

: 58169-99-6
2,3,4,6-tetrabromo-5-methyl-phenol

: 745809-51-2
acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: HI / H₂O / Heating

1.2: 2,6-lutidine

2.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 95 percent / tetrahydrofuran; pentane / 0.5 h / 0 °C

3.1: n-BuLi; TMEDA / diethyl ether; hexane; toluene / 0.03 h / -78 °C

3.2: 68 percent / various solvents / 1 h / -78 - 23 °C

4.1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 16 h / 23 °C

5.1: TBAF; HOAc / tetrahydrofuran / 0 - 23 °C

6.1: 148 mg / pyridine / 16 h

7.1: tetrahydrofuran / 14 h / 54 °C

7.2: 36 percent / air / tetrahydrofuran; diethyl ether / 0.25 h

With pyridine; 1H-imidazole; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen iodide; tert.-butyl lithium; acetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; pentane; 7.1: Doetz benzannulation;
DOI:10.1021/jo049426c

Reference yield:

: 34946-83-3
2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone

: 745809-51-2
acetic acid 3-[1-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 57 percent / sulfuric acid / 16 h

2.1: HI / H₂O / Heating

2.2: 2,6-lutidine

3.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: 95 percent / tetrahydrofuran; pentane / 0.5 h / 0 °C

4.1: n-BuLi; TMEDA / diethyl ether; hexane; toluene / 0.03 h / -78 °C

4.2: 68 percent / various solvents / 1 h / -78 - 23 °C

5.1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 16 h / 23 °C

6.1: TBAF; HOAc / tetrahydrofuran / 0 - 23 °C

7.1: 148 mg / pyridine / 16 h

8.1: tetrahydrofuran / 14 h / 54 °C

8.2: 36 percent / air / tetrahydrofuran; diethyl ether / 0.25 h

With pyridine; 1H-imidazole; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen iodide; tert.-butyl lithium; acetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; pentane; 8.1: Doetz benzannulation;
DOI:10.1021/jo049426c