4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

Base Information

Chemical Name:4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone
CAS No.:912564-47-7
Molecular Formula:C₄₈H₄₂N₈O
Molecular Weight:746.914
Hs Code.:

Synonyms:4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

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Chemical Property of 4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

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Technology Process of 4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

There total 7 articles about 4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-55-2
2-(4-toluoyl)benzoic acid

: 912564-47-7
4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: SOCl₂ / DMF / CH₂Cl₂ / 5 h / 20 °C

2.1: triethylamine / CH₂Cl₂ / 20 °C

3.1: 0.95 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3 h / Heating

4.1: azidotrimethyltin / xylene / Heating

5.1: NaOH / tetrahydrofuran; H₂O / 0.75 h / 20 °C

5.2: 0.64 g / tetrahydrofuran; H₂O / 0.17 h / 20 °C

6.1: N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / Heating

7.1: NaH / dimethylformamide / 0.33 h / 0 °C

7.2: 0.065 g / dimethylformamide / 20 °C

With sodium hydroxide; N-Bromosuccinimide; thionyl chloride; sodium hydride; azidotrimethyltin; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dibenzoyl peroxide; DMF; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; xylene;
DOI:10.1021/jm0603163

Reference yield:

: 4-(4-bromomethyl-phenyl)-2-methyl-3-(2-trityl-2H-tetrazol-5-yl)-2H-isoquinolin-1-one

: 135070-89-2
5,7-dimethyl-2-propylimidazo<4,5-b>pyridine

: 912564-47-7
4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

Guidance literature:: 5,7-dimethyl-2-propylimidazo<4,5-b>pyridine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

4-(4-bromomethyl-phenyl)-2-methyl-3-(2-trityl-2H-tetrazol-5-yl)-2H-isoquinolin-1-one; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm0603163

Reference yield:

: 912564-51-3
2-methyl-4-(4-methylphenyl)-3-cyano-1(2H)-isoquinolinone

: 912564-47-7
4-[4-[(5,7-dimethyl-2-propyl-imidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-2-methyl-3-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1(2H)-isoquinolinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: azidotrimethyltin / xylene / Heating

2.1: NaOH / tetrahydrofuran; H₂O / 0.75 h / 20 °C

2.2: 0.64 g / tetrahydrofuran; H₂O / 0.17 h / 20 °C

3.1: N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / Heating

4.1: NaH / dimethylformamide / 0.33 h / 0 °C

4.2: 0.065 g / dimethylformamide / 20 °C

With sodium hydroxide; N-Bromosuccinimide; sodium hydride; azidotrimethyltin; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm0603163