85-55-2

Basic information

• Product Name: 2-(4-Methylbenzoyl)benzoic acid
• Synonyms: 2-Carboxy-4'-methylbenzophenone;2-(4-methylbenzoyl)benzenecarboxylic acid (en);ORTHO-(PARA-TOLUOYL)-BENZOIC ACID;4-Methylbenzophenone-2'-carboxylic Acid 2-(4-Methylbenzoyl)benzoic Acid p-Toluoyl-o-benzoic Acid;2-[(4-methylphenyl)-oxomethyl]benzoic acid;Benzoic acid, 2-(4-methylbenzoyl)-;Benzoic acid, o-(p-toluoyl)- (8CI);2-(p-Toluoyl)benzoic Acid
• CAS NO: 85-55-2
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• EINECS: 201-614-3
• Mol File: 85-55-2.mol
• Article Data: 29

Chemical Properties

• Melting Point: 137-139 °C(lit.)
• Boiling Point: 342.97°C (rough estimate)
• Flash Point: 244.4 °C
• Appearance: /
• Density: 1.1783 (rough estimate)
• Vapor Pressure: 3.79E-09mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: very soluble in Benzene,Ether,Acetone,Alcohol
• PKA: 3.33±0.36(Predicted)
• Merck: 14,9539
• BRN: 2111078
• CAS DataBase Reference: 2-(4-Methylbenzoyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylbenzoyl)benzoic acid(85-55-2)
• EPA Substance Registry System: 2-(4-Methylbenzoyl)benzoic acid(85-55-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 85-55-2(Hazardous Substances Data)

Usage

Uses

2-(4-Methylbenzoyl)benzoic acid is used as a reactant in the coupling of benzoic and phenylacetic acids with aryltrifluoroborates.

InChI:InChI=1/C15H12O3/c1-10-6-8-11(9-7-10)14(16)12-4-2-3-5-13(12)15(17)18/h2-9H,1H3,(H,17,18)/p-1

Upstream product

• 85-44-9 phthalic anhydride 
• 7446-70-0 aluminium trichloride 
• 108-88-3 toluene 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 65-85-0 benzoic acid 
• 13740-72-2 4-(1-oxo-3-p-tolyl-inden-2-yl)-benzenesulfonyl chloride 
• 13304-46-6 2-phenyl-3-(p-tolyl)-1H-inden-1-one 
• 874-60-2 4-methyl-benzoyl chloride 
• 19312-06-2 4,5-dihydro-4,4-dimethyl-2-phenoxazole 
• 27331-34-6 1-(4-methylphenyl)naphthalene 
• 64-19-7 acetic acid 
• 21615-75-8 3-(4-tolyl)-isobenzofuranone 
• 20754-20-5 3-p-tolyl-acrylic acid methyl ester 
• 13740-73-3 2-<4-Sulfamoyl-phenyl>-3-p-tolyl-indon 

Downstream Products

• 99-94-5 p-Toluic acid 
• 65-85-0 benzoic acid 
• 25365-85-9 3-Methoxy-1-(4-methylphenyl)-1H-isoindol 
• 83889-40-1 3-Methoxy-1-(4-methylphenyl)-1H-isoindolium-trifluoromethansulfonat 
• 1176903-00-6 [Bu₂(2-(4-methylbenzoyl)benzoate))SnOSn(2-(4-methylbenzoyl)benzoate))Bu₂]2 
• 1610691-19-4 C₂₆H₂₆N₄O₃S₂ 
• 1610691-24-1 C₂₈H₂₈N₄O₃S₂ 
• 1610691-10-5 N-(benzylcarbamothioyl)-4-(1-oxo-4-p-tolylphthalazin-2(1H)-yl)benzenesulfonamide 
• 1610691-15-0 C₂₅H₂₄N₄O₃S₂ 

Relevant articles and documents

2-(p-Toluoyl)benzoic acid

The title compound, C15H12O3, crystallizes as a centrosymmetric dimer hydrogen bonded via the carboxylic acid groups. The carboxylic acid group is nearly coplanar with the adjacent aromatic ring, which is almost perpendicular to the tolyl ring. In contrast to all comparable o-benzoylbenzoic acid structures retrieved from the Cambridge Structural Database, the torsion angle between the carbonyl group linking both aromatic rings and the phenyl ring carrying the carboxylic acid group is less than 90°, resulting in a shorter distance between the two carbonyl O atoms.

(E)-2-Styrylanthracene-9,10-dione: A new type of fluorescent probe core and its application in specific mitochondria imaging

Herein, a new type of fluorescent probe core, (E)-2-styrylanthracene-9,10-dione (EK01), was developed which displayed strong fluorescence quantum yield (Φ = 0.867 in DMF; Φ = 0.561 in acetone; Φ = 0.616 in CH2Cl2; Φ = 0.265 in DMSO), good photostability, large stokes shift (90 nm–120 nm) and molar extinction coefficients (0.5875 × 104–0.7609 × 104 mol?1 L cm?1). During cell assays and co-localization experiments, EK01 showed excellent cell membrane permeability and low cytotoxicity against MCF-10A (human mammary epithelial cell line) and HT-29 (human colorectal adenocarcinoma cell line). Particularly, we surprisingly discovered that EK01 could selectively aggregate in mitochondria and specific stain it in a green emissive fluorescent form, which means that EK01 could be a real-time specifically monitor of mitochondria in living cells with a high signal-to-noise ratio. Hence a new mitochondria imaging method was established which is incubating EK01 with living cells for 1 h at a final concentration of 6–12 μM, then visualizing under a confocal microscope at 395 nm. It is worth noting that the fluorescence efficiency of EK01 is not outstanding in organisms, it has much stronger fluorescence efficiency in other organic solvent systems (such as DMF, acetone and CH2Cl2). Therefore, as a new type of fluorescent core that is easy to synthesis and graft, we believe that (E)-2-styrylanthracene-9,10-diones have the potential to develop a variety of fluorescence platforms applying in different fields.

Tetracyano-anthraquinone dimethane micromolecular receptor material as well as preparation method and application thereof

The invention relates to a tetracyano-anthraquinone dimethane micromolecular acceptor material as well as a preparation method and application thereof. The structure of the acceptor material is as shown in a formula I, which is described in the specification. The micromolecular acceptor material has good solubility and stability, the absorption spectrum is well matched with the solar spectrum, andthe micromolecular acceptor material can be used for organic solar cells.