(E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

Base Information

Chemical Name:(E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one
CAS No.:1610776-20-9
Molecular Formula:C₃₈H₄₉NO₄Si₂
Molecular Weight:639.982
Hs Code.:

Synonyms:(E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

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Chemical Property of (E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

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Technology Process of (E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

There total 6 articles about (E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₉H₅₃NO₇SSi₂

: 1610776-20-9
(E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2014.04.024

Reference yield:

: 1628708-15-5
1-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-propan-2-one

: 1610776-20-9
(E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 4.25 h / -78 - 20 °C

2.2: 72 h / 20 °C / Molecular sieve

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

With dimethylsulfide borane complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2014.04.024

Reference yield:

: 172843-09-3
1-O-(tert-butyldiphenylsilyl)-1,3-dihydroxy-2-propanone

: 1610776-20-9
(E)-5-((tert-butyldimethylsilyloxy)methyl)-5-((tert-butyldiphenylsilyloxy)methyl)-3-((1-methyl-1H-indol-5-yl)methylene)dihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / dichloromethane / 2 h / 0 °C

2.1: tetrahydrofuran / 2 h / 20 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 4.25 h / -78 - 20 °C

3.2: 72 h / 20 °C / Molecular sieve

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

4.2: 2 h / -78 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

With 1H-imidazole; dimethylsulfide borane complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2014.04.024