N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride

Base Information

• Chemical Name: N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride
• CAS No.: 1018856-67-1
• Molecular Formula: C₂₃H₂₃ClN₂O₂*ClH
• Molecular Weight: 431.362

Synonyms:N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride

Chemical Property of N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride

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Technology Process of N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride

There total 1 articles about N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-(2-cyclopropylethoxy)-N-[3-(hydroxymethyl)-8-methylquinolin-7-yl]benzamide (1018856-66-0) → N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride (1018856-67-1)

Guidance literature:

With thionyl chloride; at -78 - 30 ℃; Inert atmosphere;

Reference yield: 37.0%

3-methylthio-1-propanamine (4104-45-4) + N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride (1018856-67-1) → 4-(2-cyclopropylethoxy)-N-[8-methyl-3-({[3-(methylthio)propyl]amino}methyl)quinolin-7-yl]benzamide (1190044-32-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 40 ℃; for 17.5h;

Reference yield: 36.0%

N-[3-(chloromethyl)-8-methylquinolin-7-yl]-4-(2-cyclopropylethoxy)benzamide hydrochloride (1018856-67-1) + 1,1-dioxohexahydro-1λ6-thiopyran-4-ylamine hydrochloride (116529-31-8) → 4-(2-cyclopropylethoxy)-N-(3-{[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]methyl}-8-methylquinolin-7-yl)benzamide (1190043-90-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 100h;

upstream raw materials:

4-(2-cyclopropylethoxy)-N-[3-(hydroxymethyl)-8-methylquinolin-7-yl]benzamide

Downstream raw materials:

4-(2-cyclopropylethoxy)-N-[8-methyl-3-({[3-(methylthio)propyl]amino}methyl)quinolin-7-yl]benzamide

4-(2-cyclopropylethoxy)-N-(3-{[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]methyl}-8-methylquinolin-7-yl)benzamide

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