3-Methylthiopropylamine

Base Information

• Chemical Name: 3-Methylthiopropylamine
• CAS No.: 4104-45-4
• Molecular Formula: C4H12NS+
• Molecular Weight: 105.204
• Hs Code.: 2930909090
• European Community (EC) Number: 223-875-2
• UNII: 1IAP0CGD5S
• DSSTox Substance ID: DTXSID1063300
• Nikkaji Number: J146.566J
• Wikidata: Q21099103
• Metabolomics Workbench ID: 50599
• Mol file: 4104-45-4.mol

Synonyms:3-methylthiopropylamine;3-MTPA

Chemical Property of 3-Methylthiopropylamine

Chemical Property:

• Appearance/Colour: CLEAR COLOURLESS LIQUID
• Vapor Pressure: 1.51mmHg at 25°C
• Refractive Index: n20/D 1.4940(lit.)
• Boiling Point: 169 °C(lit.)
• Flash Point: 62 °C
• PSA: 51.32000
• Density: 0.938 g/mL at 25 °C(lit.)
• LogP: 1.39850
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water. Soluble in ethanol.
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 105.06122053
• Heavy Atom Count: 6
• Complexity: 23.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Methylthio)propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,C
• Hazard Codes: Xi,C
• Statements: 37/38-41
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CSCCCN
• Uses: 3-(Methylthio)propylamine can be used in the synthesis of rhodium(III)complexes involving acyclic diaminedithioether(DADTE)ligands.

Technology Process of 3-Methylthiopropylamine

There total 15 articles about 3-Methylthiopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

2-<2-(Methylthio)propyl>-1H-isoindole-1,3(2H)-dione (52096-79-4) → 3-methylthio-1-propanamine (4104-45-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Wavelength; Microwave irradiation; Sonication; Reflux;

Reference yield: 72.8%

L-methionine (63-68-3,26062-47-5,58576-49-1) → 3-methylthio-1-propanamine (4104-45-4)

Guidance literature:

cyclohexenone; In various solvent(s); at 154 ℃; for 2h;

DOI:10.1246/cl.1986.893

Reference yield: 32.0%

→ [αS-(αR*,γR*,δR*)]γ-hydroxy-α-(1-methylethyl)-δ-[(4-methylpentyl)amino]-N-[3-(methylthio)propyl]cyclohexanehexanamide hydrochloride (192386-72-4) + 3-methylthio-1-propanamine (4104-45-4)

Guidance literature:

upstream raw materials:

2-<2-(Methylthio)propyl>-1H-isoindole-1,3(2H)-dione

3-(methylthio)propionitrile

DL-methionine

L-Cysteine

Downstream raw materials:

iberverin

N-(3-methylsulfanyl-propyl)-N'-phenyl-thiourea

reductiline

7-Chloro-3-(3,4-dichloro-phenyl)-10-hydroxy-1-[(E)-3-methylsulfanyl-propylimino]-1,3,4,10-tetrahydro-2H-acridin-9-one

Refernces

• 1、 -. "Method for preparing 3-methylthio propylamine". Paragraph 0007; 0023; 0027; 0031; 0035. . Retrieved 2018/03/24.
• 2、 Barata-Vallejo, Sebastian,Ferreri, Carla,Postigo, Al,Chatgilialoglu, Chryssostomos. "Radiation chemical studies of methionine in aqueous solution: Understanding the role of molecular oxygen". scheme or table. p. 258 - 263. Retrieved 2011/02/26.