2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

Base Information

Chemical Name:2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione
CAS No.:606137-19-3
Molecular Formula:C₂₃H₂₀F₆N₂O₃
Molecular Weight:486.414
Hs Code.:

Synonyms:2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

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Chemical Property of 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

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Technology Process of 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

There total 6 articles about 2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 606137-09-1
3-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-3-phenyl-cyclobutanone

: 151-50-8
potassium cyanide

: 506-87-6,6721-33-1,10361-29-2
ammonium carbonate

: 606137-19-3
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

: 606137-20-6
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

Guidance literature:: With water; In ethanol; at 90 ℃; for 36h;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 530441-99-7
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-1-phenyl-ethanone

: 606137-19-3
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / NaNH₂ / tetrahydrofuran / 24 h / 20 °C

2: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

3: Zn dust; AcOH / 48 h / 20 °C

4: 46 percent / H₂O / ethanol / 36 h / 90 °C

With water; copper; sodium amide; acetic acid; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; 1: Wittig reaction;
DOI:10.1016/j.bmcl.2006.04.031

Reference yield:

: 606137-78-4
1-[(R)-1-(2-Phenyl-allyloxy)-ethyl]-3,5-bis-trifluoromethyl-benzene

: 606137-19-3
2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxymethyl]-2-phenyl-5,7-diaza-spiro[3.4]octane-6,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Zn-Cu / diethyl ether; 1,2-dimethoxy-ethane / 120 h / Heating

2: Zn dust; AcOH / 48 h / 20 °C

3: 46 percent / H₂O / ethanol / 36 h / 90 °C

With water; copper; acetic acid; zinc; In 1,2-dimethoxyethane; diethyl ether; ethanol;
DOI:10.1016/j.bmcl.2006.04.031