530441-99-7Relevant articles and documents
Cyclobutane derivatives as potent NK1 selective antagonists
Wrobleski, Michelle Laci,Reichard, Gregory A.,Paliwal, Sunil,Shah, Sapna,Tsui, Hon-Chung,Duffy, Ruth A.,Lachowicz, Jean E.,Morgan, Cynthia A.,Varty, Geoffrey B.,Shih, Neng-Yang
, p. 3859 - 3863 (2007/10/03)
A series of novel cyclobutane derivatives as potent and selective NK1 receptor antagonists is described. Several compounds in this series exhibited high in vitro binding affinity (Ki {less-than or slanted equal to} 1 nM), and potent
Two complementary, diversity-driven asymmetric syntheses of a 2,2-disubstituted piperidine NK1 antagonist
Xiao, Dong,Wang, Cheng,Palani, Anandan,Reichard, Gregory,Aslanian, Robert,Shih, Neng-Yang,Buevich, Alexei
, p. 2596 - 2598 (2007/10/03)
Two diversity-driven asymmetric syntheses of a potent NK1 receptor antagonist 1 were achieved. These syntheses provided two complementary approaches that were well positioned for further modifications of several different sites of medicinal che