1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

Base Information

Chemical Name:1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate
CAS No.:1427321-70-7
Molecular Formula:C₄₅H₅₄N₂O₉SSi
Molecular Weight:827.083
Hs Code.:

1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

Synonyms:1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

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Chemical Property of 1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

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Technology Process of 1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

There total 5 articles about 1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 4530-20-5
BOC-glycine

: 1427321-90-1
N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-{7-[(tert-butyldiphenylsilyl)oxy]-3-hydroxyhept-1-yn-1-yl}-4-methylbenzenesulfonamide

: 1427321-70-7
1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 1.83333h;
DOI:10.1021/ol400402n

Reference yield:

: 1427321-85-4
1-bromo-5-(2-chlorophenyl)pent-1-yn-3-ol

: 1427321-70-7
1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 3 h / 80 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.83 h / 0 - 20 °C

With dmap; potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; toluene;
DOI:10.1021/ol400402n

Reference yield:

: 131216-47-2
5-(tert-butyldiphenylsilyloxy)pentanal

: 1427321-70-7
1-[N-(benzo[d][1,3]dioxol-5-ylmethyl)(4-methylbenzene)sulfonamido]-7-[(tertbutyldiphenylsilyl)oxy]hept-1-yn-3-yl 2-((tert-butoxycarbonyl)amino)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane / 0.5 h / -78 °C

1.2: 1.58 h / -78 - 0 °C

2.1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Darkness

3.1: hydrogenchloride / tetrahydrofuran; water / 0.5 h / 20 °C

4.1: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 3 h / 80 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1.83 h / 0 - 20 °C

With hydrogenchloride; dmap; potassium phosphate; N-Bromosuccinimide; n-butyllithium; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; hexane; dichloromethane; water; acetone; toluene;
DOI:10.1021/ol400402n