Technology Process of 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-formyl-1H-imidazol-2-yl)-amide
There total 12 articles about 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-formyl-1H-imidazol-2-yl)-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-amino-4-diethoxymethyl-imidazole-1-carboxylic acid tert-butyl ester; 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
With
toluene-4-sulfonic acid;
In
water; acetone;
at 50 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / ethanol / 15 - 30 °C / Inert atmosphere
2.1: ethanol; water / 3 h / Reflux
3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere
4.1: Selectfluor / acetonitrile / 0.5 h / 20 °C
5.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C / Inert atmosphere
6.1: potassium hydroxide / water; ethylene glycol / 4 h / 150 °C
6.2: pH 5
7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C
7.2: 2 h / 50 °C
With
sodium tetrahydroborate; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; Selectfluor; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; ethanol; water; ethylene glycol; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere
2.1: Selectfluor / acetonitrile / 0.5 h / 20 °C
3.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C / Inert atmosphere
4.1: potassium hydroxide / water; ethylene glycol / 4 h / 150 °C
4.2: pH 5
5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C
5.2: 2 h / 50 °C
With
sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; Selectfluor; N-ethyl-N,N-diisopropylamine; potassium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1-methyl-pyrrolidin-2-one; ethanol; water; ethylene glycol; N,N-dimethyl-formamide; toluene; acetonitrile;
