8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

Base Information

Chemical Name:8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide
CAS No.:1197331-87-5
Molecular Formula:C₂₂H₂₀F₂N₆O₃
Molecular Weight:454.436
Hs Code.:

Synonyms:8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

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Chemical Property of 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

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Technology Process of 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

There total 13 articles about 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197331-86-4
8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-formyl-1H-imidazol-2-yl)-amide

: 74-89-5
methylamine

: 1197331-87-5
8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; water; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 15155-41-6
4,7-dibromobenzo[c][1,2,5]thiadiazole

: 1197331-87-5
8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium tetrahydroborate / ethanol / 15 - 30 °C / Inert atmosphere

2.1: ethanol; water / 3 h / Reflux

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere

4.1: 1-methyl-pyrrolidin-2-one / 2 h / 180 °C / Inert atmosphere

5.1: potassium hydroxide / ethylene glycol / 3 h / 150 °C

5.2: pH 5

6.1: sulfuric acid / 7 h / Reflux

7.1: 2,6-dichloro-1-fluoropyridin-1-ium tetrafluoroborate / acetonitrile / -5 - 20 °C

8.1: lithium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

8.2: pH 6

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

9.2: 2 h / 50 °C

10.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; sulfuric acid; sodium tris(acetoxy)borohydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; lithium hydroxide; 2,6-dichloro-1-fluoropyridin-1-ium tetrafluoroborate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 148231-12-3
5,8-dibromoquinoxaline

: 1197331-87-5
8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-methylaminomethyl-1H-imidazol-2-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; toluene / 2 h / 105 °C / Inert atmosphere

2.1: Selectfluor / acetonitrile / 0.5 h / 20 °C

3.1: 1-methyl-pyrrolidin-2-one / 4 h / 150 °C / Inert atmosphere

4.1: potassium hydroxide / water; ethylene glycol / 4 h / 150 °C

4.2: pH 5

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

5.2: 2 h / 50 °C

6.1: sodium tris(acetoxy)borohydride / dichloromethane; water / 24 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; Selectfluor; N-ethyl-N,N-diisopropylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide; toluene; acetonitrile;