3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

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Chemical Name:3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide
CAS No.:1610671-10-7
Molecular Formula:C₂₃H₂₀N₆O₂
Molecular Weight:412.451
Hs Code.:

Synonyms:3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

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Chemical Property of 3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

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Technology Process of 3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

There total 7 articles about 3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610671-16-3
N-(4-cyanophenyl)-3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

: 1610671-10-7
3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Guidance literature:: With palladium on activated charcoal; hydrogen; acetic acid; In ethanol; for 0.5h;

Reference yield:

: 947533-23-5
(4-(cyanomethoxy)phenyl)boronic acid

: 1610671-10-7
3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dipotassium hydrogenphosphate / tetrahydrofuran; water / 0.75 h / 150 °C / Microwave irradiation

2.1: sodium tetrahydroborate; nickel dichloride / ethanol / 0.17 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

4.1: sodium hydroxide / acetonitrile / 12 h / 20 °C

4.2: 20 °C

5.1: dichloromethane / 20 °C

6.1: acetic acid; palladium on activated charcoal; hydrogen / ethanol / 0.5 h

With sodium tetrahydroborate; dipotassium hydrogenphosphate; palladium on activated charcoal; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; nickel dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling;

Reference yield:

: 1607830-93-2
methyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate

: 1610671-10-7
3-[4-(2-aminoethoxy)phenyl]-N-(4-cyanophenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dipotassium hydrogenphosphate / tetrahydrofuran; water / 0.75 h / 150 °C / Microwave irradiation

2.1: sodium tetrahydroborate; nickel dichloride / ethanol / 0.17 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

4.1: sodium hydroxide / acetonitrile / 12 h / 20 °C

4.2: 20 °C

5.1: dichloromethane / 20 °C

6.1: acetic acid; palladium on activated charcoal; hydrogen / ethanol / 0.5 h

With sodium tetrahydroborate; dipotassium hydrogenphosphate; palladium on activated charcoal; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; nickel dichloride; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling;