methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Base Information

• Chemical Name: methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate
• CAS No.: 1610671-11-8
• Molecular Formula: C₁₆H₁₂N₄O₃
• Molecular Weight: 308.296
• Mol file: 1610671-11-8.mol

Synonyms:methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Chemical Property of methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

There total 1 articles about methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-(cyanomethoxy)phenyl)boronic acid (947533-23-5) + methyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate (1607830-93-2) → methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate (1610671-11-8)

Guidance literature:

With dipotassium hydrogenphosphate; In tetrahydrofuran; water; at 150 ℃; for 0.75h; Microwave irradiation;

Reference yield:

methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate (1610671-11-8) → methyl 3-(4-(2-aminoethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate (1610671-12-9)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In ethanol; at 0 ℃; for 0.166667h;

Reference yield:

methyl 3-(4-(cyanomethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate (1610671-11-8) → 3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate (1610671-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; nickel dichloride / ethanol / 0.17 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; nickel dichloride; In ethanol; dichloromethane;

upstream raw materials:

(4-(cyanomethoxy)phenyl)boronic acid

methyl 3-bromoimidazo[1,2-a]pyrazine-6-carboxylate

Downstream raw materials:

methyl 3-(4-(2-aminoethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carboxylate

3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)imidazo[1,2-a]pyrazine-6-carbonyl chloride

N-(4-cyanophenyl)-3-(4-(2-((4-methoxybenzyl)amino)ethoxy)phenyl)-N-methylimidazo[1,2-a]pyrazine-6-carboxamide