methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate
CAS No.:887918-08-3
Molecular Formula:C₁₉H₂₁NO₄S
Molecular Weight:359.446
Hs Code.:

Synonyms:methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

There total 2 articles about methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887917-96-6
methyl (E)-N-[(m-methylphenyl)methylene]glycinate

: 5535-48-8
PVS

: methyl (2S,4R,5S)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

: 887918-08-3
methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

Guidance literature:: With tetrakis(acetonitrile)copper(I) perchlorate; Taniaphos; triethylamine; In toluene; Title compound not separated from byproducts; cooling;
DOI:10.1021/ol060314c

Reference yield:

: 620-23-5
m-tolyl aldehyde

: 887918-08-3
methyl (2R,4S,5R)-4-(phenylsulfonyl)-5-(3-tolyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / MgSO₄; Et₃N / CH₂Cl₂

2: Cu(CH₃CN)4ClO₄; Taniaphos; Et₃N / toluene / cooling

With tetrakis(acetonitrile)copper(I) perchlorate; Taniaphos; magnesium sulfate; triethylamine; In dichloromethane; toluene;
DOI:10.1021/ol060314c