5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

Base Information

Chemical Name:5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride
CAS No.:742055-21-6
Molecular Formula:C₁₈H₁₈ClNO₂
Molecular Weight:315.799
Hs Code.:

Synonyms:5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

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Chemical Property of 5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

Chemical Property:

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Technology Process of 5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

There total 7 articles about 5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: [2-(8-methoxy-2,3-dihydro-1,4-benzoxazepin-5-yl)phenyl]ethanol hydrochloride

: 742055-21-6
5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

Guidance literature:: With trichlorophosphate; at 60 ℃; for 0.25h;

Reference yield:

: 150-19-6
O-methylresorcine

: 742055-21-6
5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 52 percent / 16 h / 180 °C

2: 65 percent / orthophosphoric acid / H₂O / 16 h / Heating

3: 22 percent / NH₄Cl / 8 h / 120 °C

4: 95 percent / CHCl₃; pyridine / 20 °C

5: 47 percent / phosphoric trichloride / acetonitrile / 6 h / Heating

6: 69 percent / KOH; water / ethanol / 12 h / 20 °C

7: 80 percent / phosphoric trichloride / 0.25 h / 60 °C

With potassium hydroxide; phosphoric acid; water; ammonium chloride; trichlorophosphate; In pyridine; ethanol; chloroform; water; acetonitrile;

Reference yield:

: 26378-67-6
2-(3-methoxyphenoxy)ethylamine hydrochloride

: 742055-21-6
5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: 22 percent / NH₄Cl / 8 h / 120 °C

2: 95 percent / CHCl₃; pyridine / 20 °C

3: 47 percent / phosphoric trichloride / acetonitrile / 6 h / Heating

4: 69 percent / KOH; water / ethanol / 12 h / 20 °C

5: 80 percent / phosphoric trichloride / 0.25 h / 60 °C

With potassium hydroxide; water; ammonium chloride; trichlorophosphate; In pyridine; ethanol; chloroform; acetonitrile;