4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

Base Information

Chemical Name:4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester
CAS No.:876162-20-8
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

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Chemical Property of 4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

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Technology Process of 4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

There total 4 articles about 4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 876162-08-2
2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenol

: 2969-81-5
Ethyl 4-bromobutyrate

: 876162-20-8
4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 3h;
DOI:10.1002/jccs.200500050

Reference yield:

: 876161-98-7
3-(2-isopropoxyphenyl)-5-adamantan-1-yl-[1,2,4]oxadiazole

: 876162-20-8
4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / BCl₃ / CH₂Cl₂ / 4 h / 0 °C

2: 86 percent / K₂CO₃ / dimethylformamide / 3 h / 70 - 80 °C

With boron trichloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jccs.200500050

Reference yield:

: 611-20-1
salicylonitrile

: 876162-20-8
4-[2-(5-adamantan-1-yl-[1,2,4]oxadiazol-3-yl)phenoxy]butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / K₂CO₃ / dimethylformamide / 60 - 70 °C

2.1: 95 percent / NH₂OH*HCl; aq. NaOH / 80 - 90 °C

3.1: N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 4 h

3.2: 74 percent / pyridine / 4 h / Heating

4.1: 94 percent / BCl₃ / CH₂Cl₂ / 4 h / 0 °C

5.1: 86 percent / K₂CO₃ / dimethylformamide / 3 h / 70 - 80 °C

With sodium hydroxide; hydroxylamine hydrochloride; boron trichloride; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jccs.200500050