(S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

Base Information

Chemical Name:(S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate
CAS No.:1334386-03-6
Molecular Formula:C₂HF₃O₂*C₁₃H₁₆N₂O₄S
Molecular Weight:410.371
Hs Code.:

Synonyms:(S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

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Chemical Property of (S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

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Technology Process of (S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

There total 5 articles about (S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 93794-39-9
2-chloro-6-methoxybenzo[d]oxazole

: 52-67-5
3,3-dimethyl-D-cysteine

: 76-05-1
trifluoroacetic acid

: 1334386-03-6
(S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

Guidance literature:: 2-chloro-6-methoxybenzo[d]oxazole; 3,3-dimethyl-D-cysteine; With sodium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 3h;

With hydrogenchloride; In water; dimethyl sulfoxide; pH=3 - 4;

trifluoroacetic acid; In water; acetonitrile; Flash chromatography;

Reference yield:

: 150-19-6
O-methylresorcine

: 1334386-03-6
(S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; propionic acid / water / 1 h / -5 °C

1.2: 16 h / -5 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3.5 h / 20 °C

3.1: ethanol / 18 h / Reflux

4.1: thionyl chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.1: sodium hydroxide / dimethyl sulfoxide / 3 h / 20 °C

5.2: pH 3 - 4

5.3: Flash chromatography

With thionyl chloride; hydrogen; propionic acid; sodium hydroxide; sodium nitrite; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 704-14-3
3-methoxy-6-nitro-phenol

: 1334386-03-6
(S)-2-(2-hydroxy-4-methoxyphenylamino)-thiazoline-5,5-dimethyl-4-carboxylic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3.5 h / 20 °C

2.1: ethanol / 18 h / Reflux

3.1: thionyl chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.1: sodium hydroxide / dimethyl sulfoxide / 3 h / 20 °C

4.2: pH 3 - 4

4.3: Flash chromatography

With thionyl chloride; hydrogen; sodium hydroxide; palladium 10% on activated carbon; N,N-dimethyl-formamide; In ethanol; dimethyl sulfoxide; ethyl acetate;