2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

Base Information

Chemical Name:2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide
CAS No.:177559-79-4
Molecular Formula:C₂₅H₂₈N₂O₅
Molecular Weight:436.508
Hs Code.:

Synonyms:2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

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Chemical Property of 2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

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Technology Process of 2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

There total 8 articles about 2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 2969-81-5
Ethyl 4-bromobutyrate

: 177559-75-0
2-(3-Benzyl-2-ethyl-7-hydroxyindolizin-1-yl)glyoxylamide

: 177559-79-4
2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 24103-75-1
4-methoxy-2-methylpyridine

: 177559-79-4
2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 8 steps

1: ethyl acetate / 0.5 h / 70 °C

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

3: 70.5 percent / benzene / 4 h / Heating

4: 22 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

5: tetrahydrofuran / 1 h / 0 °C

6: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

7: 49 percent / BBr₃ / CH₂Cl₂

8: 54 percent / NaH / dimethylformamide / Ambient temperature

With ammonium hydroxide; aluminium trichloride; borane; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 182116-41-2
2-ethyl-7-methoxyindolizine

: 177559-79-4
2-(3-Benzyl-7-(3-carbethoxypropyloxy)-2-ethylindolizin-1-yl)glyoxylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 70.5 percent / benzene / 4 h / Heating

2: 22 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

3: tetrahydrofuran / 1 h / 0 °C

4: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

5: 49 percent / BBr₃ / CH₂Cl₂

6: 54 percent / NaH / dimethylformamide / Ambient temperature

With ammonium hydroxide; aluminium trichloride; borane; boron tribromide; sodium hydride; tert-butylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q