4-Methoxy-2-methylpyridine

Base Information

• Chemical Name: 4-Methoxy-2-methylpyridine
• CAS No.: 24103-75-1
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2933399090
• European Community (EC) Number: 800-486-1
• DSSTox Substance ID: DTXSID60406165
• Wikidata: Q82211065
• Mol file: 24103-75-1.mol

Synonyms:4-methoxy-2-methylpyridine;24103-75-1;Pyridine, 4-methoxy-2-methyl-;4-methoxy-2-picoline;2-methyl-4-methoxypyridine;SCHEMBL3805415;AMY6270;DTXSID60406165;MWVSSYOXUWYVTJ-UHFFFAOYSA-N;ZAA10375;MFCD06253892;AKOS002663445;CS-W005919;SB11589;DS-16812;FT-0764366;EN300-184425;H11395;A878018

Chemical Property of 4-Methoxy-2-methylpyridine

Chemical Property:

• Vapor Pressure: 1.01mmHg at 25°C
• Melting Point: 109.3 °C
• Refractive Index: 1.494
• Boiling Point: 184.4 °C at 760 mmHg
• PKA: 7.27±0.10(Predicted)
• Flash Point: 65.5 °C
• PSA: 22.12000
• Density: 1.001g/cm³
• LogP: 1.39860
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Methoxy-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=C1)OC

Technology Process of 4-Methoxy-2-methylpyridine

There total 4 articles about 4-Methoxy-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-bis-(2,2'-dimethylpyridine) (100421-65-6)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Further byproducts given. Yields of byproduct given;

Reference yield: 86.5%

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-2-methylpyridine N,N'-dioxide (106882-31-9) + 4,4'-azo-bis-(2,2'-dimethylpyridine) (100421-65-6)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Product distribution; other catalysts, other solvents, other temperatures, other pressures;

Reference yield:

2-methyl-4-nitropyridine N-oxide (5470-66-6) → 3-methyl-4-pyridinamine (18437-58-6) + 4-methoxy-2-methylpyridine (24103-75-1) + 4-amino-2-methylpyridine N-oxide (14045-17-1) + 4,4'-azo-2-methylpyridine N,N'-dioxide (106882-31-9)

Guidance literature:

With hydrogen; nickel on kieselguhr; In methanol; at 120 ℃; for 0.5h; under 98800.1 Torr; Yield given. Further byproducts given. Yields of byproduct given;

upstream raw materials:

2-methyl-4-nitropyridine N-oxide

Downstream raw materials:

3-Cyclohexylmethyl-2-ethyl-7-methoxyindolizine

3-Cyclohexylcarbonyl-2-ethyl-7-methoxyindolizine

3-Benzyl-2-ethyl-7-methoxyindolizine

3-Benzoyl-2-ethyl-7-methoxyindolizine

Refernces

• 1、 Ovchinnikov, V. G.,Litvinenko, G. S.,Maksimenko, N. M.,Sherstyuk, A. I.,Levkov, V. A.. "CATALYTIC HYDROGENATION OF 4-NITRO-2-METHYLPYRIDINE N-OXIDE". . p. 1460 - 1468. Retrieved 2007/10/02.