2-Propanone, 1-(3-methyl-5-isoxazolyl)- (8CI,9CI)

Base Information

• Chemical Name: 2-Propanone, 1-(3-methyl-5-isoxazolyl)- (8CI,9CI)
• CAS No.: 19986-25-5
• Molecular Formula: C7H9 N O2
• Molecular Weight: 139.15186
• Hs Code.: 2934999090
• Mol file: 19986-25-5.mol

Synonyms:1-(3-Methyl-5-isoxazolyl)-2-propanone

Chemical Property of 2-Propanone, 1-(3-methyl-5-isoxazolyl)- (8CI,9CI)

Chemical Property:

• PSA: 43.10000
• LogP: 1.11450

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propanone, 1-(3-methyl-5-isoxazolyl)- (8CI,9CI)

There total 8 articles about 2-Propanone, 1-(3-methyl-5-isoxazolyl)- (8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-methoxy-N-methyl-2-(3-methylisoxazol-5-yl)acetamide → 1-(3-methylisoxazol-5-yl)propan-2-one (19986-25-5)

Guidance literature:

With methylmagnesium bromide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

3,5-dimethyl-1,2-oxazole (300-87-8) + N-Methoxy-N-methylacetamide (78191-00-1) → 1-(3-methylisoxazol-5-yl)propan-2-one (19986-25-5)

Guidance literature:

With ammonium acetate; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

Reference yield:

3,3'-dimethyl-[4,5']biisoxazolyl-5-ol (6984-93-6) → 1-(3-methylisoxazol-5-yl)propan-2-one (19986-25-5)

Guidance literature:

3,3'-dimethyl-[4,5']biisoxazolyl-5-ol; With iron; acetic acid; In methanol; at 60 ℃; for 1h; Heating / reflux;

at 60 ℃; for 0.333333h;

upstream raw materials:

3,8-dimethyl-1,6-dioxa-2,7-diaza-spiro[4.4]nona-2,7-diene

3,5-dimethyl-1,2-oxazole

ethyl acetate

3,3'-dimethyl-[4,5']biisoxazolyl-5-ol

Downstream raw materials:

3-acetyl-4-methyl-5-(3-methyl-5-isoxazolyl)-6-phenyl-2-pyridone

Refernces

• 1、 -. "BENZO [B] ISOXAZOLOAZEPINE BROMODOMAIN INHIBITORS AND USES THEREOF". Paragraph 00233; 00234. . Retrieved 2014/01/08.
• 2、 -. "Novel Compounds". . . Retrieved 2008/06/13.